Organoid as a culture system for viral vaccine strains.
10.7774/cevr.2018.7.2.145
- Author:
Kee Jong HONG
1
;
Sang Hwan SEO
Author Information
1. Interpark Bio-convergence Center, Seoul, Korea. Sanghwan.Seo@ivi.int
- Publication Type:Brief Communication
- Keywords:
Organoids;
Viral vaccines;
Virus cultivation;
Viral gene mutation
- MeSH:
Host-Pathogen Interactions;
Humans;
In Vitro Techniques;
Organoids*;
Viral Vaccines;
Virus Cultivation
- From:Clinical and Experimental Vaccine Research
2018;7(2):145-148
- CountryRepublic of Korea
- Language:English
-
Abstract:
Organoid is an in vitro multicellular form mimicking in vivo organ. Its similarity to human organ including cellular organization, molecular expression patterns, as well as genetic signatures enables to study the characteristics of infectious agents and host-pathogen interaction. For the features of organoid, this system also can be potentially used to cultivate currently uncultivable viruses of vaccine candidates. This paper will briefly describe problems in the current culture system for virus production and the possibility of organoid as culture system for viral vaccine and their current limitations that should be solved to meet the goal.
