A Case of Nodular Colloid Degeneration in a 40-year-old Woman.
- Author:
Byeol HAN
1
;
Won Mi LEE
;
Sook Ja SON
;
June Hyunkyung LEE
;
Tae Young HAN
Author Information
1. Department of Dermatology, Nowon Eulji Medical Center, Eulji University, Seoul, Korea. dermahan@gmail.com
- Publication Type:Case Report
- Keywords:
Colloid degeneration of the skin;
Colloid milium;
Nodular colloid degeneration
- MeSH:
Adult*;
Colloids*;
Congo Red;
Dermis;
Diagnosis, Differential;
Elastic Tissue;
Female;
Forehead;
Humans;
Skin
- From:Korean Journal of Dermatology
2018;56(6):393-395
- CountryRepublic of Korea
- Language:English
-
Abstract:
Colloid degeneration of the skin is a rare, distinct clinicopathological entity characterized by the deposition of colloid material in the dermis. Nodular colloid degeneration (NCD) is a clinical variant of colloid degeneration of the skin. Herein, we report the case of a 40-year-old woman who presented with a 3-year history of multiple asymptomatic yellowish-brown, indurated papules and plaques on her forehead. Histopathologic examination of the lesion revealed deposition of amorphous pale pink homogenous colloid material with irregular clefts, fissures, and scattered pyknotic nuclei in the upper dermis. The material was negative for Congo red staining, and periodic acid-Schiff and Masson's trichrome staining revealed positive reactivity. Scattered fragmented elastic fibers were present in the colloid material on Verhoeff—Van Gieson staining. The patient was diagnosed with NCD. We propose that NCD should be considered in the differential diagnosis of long-standing facial nodules and plaques.
