Nonimmunity against hepatitis B virus infection in patients newly diagnosed with inflammatory bowel disease.
- Author:
Seong Jae YEO
1
;
Hyun Seok LEE
;
Byung Ik JANG
;
Eun Soo KIM
;
Seong Woo JEON
;
Sung Kook KIM
;
Kyeong Ok KIM
;
Yoo Jin LEE
;
Hyun Jik LEE
;
Kyung Sik PARK
;
Yun Jin JUNG
;
Eun Young KIM
;
Chang Heon YANG
Author Information
- Publication Type:Original Article
- Keywords: Inflammatory bowel disease; Colitis, ulcerative; Crohn disease; Hepatitis B virus; Vaccination
- MeSH: Colitis, Ulcerative; Crohn Disease; Diagnosis; Hepatitis B Surface Antigens; Hepatitis B virus*; Hepatitis B*; Hepatitis*; Humans; Inflammatory Bowel Diseases*; Multivariate Analysis; Prevalence; Prospective Studies; Risk Factors; Vaccination
- From:Intestinal Research 2018;16(3):400-408
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: This study aimed to elucidate the prevalence of hepatitis B virus (HBV) serologic markers in Korean patients newly diagnosed with, but not yet treated for inflammatory bowel disease (IBD). METHODS: We prospectively enrolled 210 patients newly diagnosed with IBD (109 with ulcerative colitis and 101 with Crohn's disease). Hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), and hepatitis B core antibody (anti-HBc) levels were measured and compared with those of 1,100 sex- and age-matched controls. RESULTS: The prevalence of chronic HBV infection (positive HBsAg, positive anti-HBc, and negative anti-HBs results) and past infection (negative HBsAg, positive anti-HBc, and positive or negative anti-HBs results) were not significantly different between the patients and controls (chronic HBV infection: IBD, 3.8% vs. control, 4.9%, P=0.596; past infection: IBD, 26.2% vs. control, 28.8%, P=0.625). The patients with IBD aged < 20 years were at a higher susceptibility risk (nonimmune) for HBV infection than the controls (IBD, 41.5% vs. control, 22.4%; P=0.018). In the multivariate analysis, an age of < 20 years (P=0.024) and symptom duration of ≥12 months before diagnosis (P=0.027) were identified as independent risk factors for nonimmunity against HBV infection. CONCLUSIONS: The patients newly diagnosed with IBD were susceptible to HBV infection. The frequency of nonimmunity was high, especially in the patients aged < 20 years and those with a longer duration of symptoms before diagnosis. Therefore, it is necessary to screen for HBV serologic markers and generate a detailed vaccination plan for patients newly diagnosed with IBD.
