The association between new generation oral contraceptive pill and the development of inflammatory bowel diseases.
- Author:
Santosh SANAGAPALLI
1
;
Yanna KO
;
Viraj KARIYAWASAM
;
Siew C NG
;
Whitney TANG
;
Hithanadura Janaka DE SILVA
;
Minhu CHEN
;
Kaichun WU
;
Satimai ANIWAN
;
Ka Kei NG
;
David ONG
;
Qin OUYANG
;
Ida HILMI
;
Marcellus SIMADIBRATA
;
Pises PISESPONGSA
;
Saranya GOPIKRISHNA
;
Rupert W LEONG
Author Information
- Publication Type:Original Article
- Keywords: Inflammatory bowel diseases; Contraceptives, oral
- MeSH: Case-Control Studies; Cohort Studies; Colitis, Ulcerative; Contraceptives, Oral; Crohn Disease; Female; Humans; Inflammatory Bowel Diseases*; Prospective Studies; Smoke; Smoking
- From:Intestinal Research 2018;16(3):409-415
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: To examine the association between use of oral contraceptive pills (OCPs) and the risk of developing inflammatory bowel diseases (IBD), in a modern cohort. METHODS: A prospective nested case-control study across sites in the Asia-Pacific region was conducted; involving female IBD cases and asymptomatic controls. Subjects completed a questionnaire addressing questions related to OCP use. Primary outcome was the risk of development of IBD of those exposed to OCP versus non-exposure. Secondary outcomes were development of Crohn's disease (CD) versus ulcerative colitis (UC), and whether age of first use of OCP use may be associated with risk of IBD. RESULTS: Three hundred and forty-eight female IBD cases (41% CD, median age: 43 years) and 590 female age-matched controls were recruited. No significant association was found between OCP use and the risk of IBD (odds ratio [OR], 1.65; 95% confidence interval, 0.77–3.13; P=0.22), CD (OR, 1.55) or UC (OR, 1.01). The lack of association persisted when results were adjusted for age and smoking. IBD cases commenced OCP use at a younger age than controls (18 years vs. 20 years, P=0.049). CONCLUSIONS: In this large cohort of subjects from the Asia-Pacific region, we found a modest but not significantly increased risk of developing IBD amongst OCP users.
