What nutritional factors influence bone mineral density in Crohn's disease patients?.
- Author:
Fernanda GOMES COQUEIRO
1
;
Raquel ROCHA
;
Camilla Almeida MENEZES
;
Mirella BRASIL LOPES
;
Vanessa ROSA OLIVEIRA
;
Flora Maria Lorenzo FORTES
;
Genoile Oliveira SANTANA
Author Information
- Publication Type:Original Article
- Keywords: Crohn disease; Bone density; Body mass index; Waist circumference; Nutritional features
- MeSH: Absorptiometry, Photon; Body Composition; Body Mass Index; Bone Density*; Calcium; Crohn Disease*; Densitometry; Femur Neck; Humans; Linear Models; Lumbar Vertebrae; Magnesium; Phosphorus; Prevalence; Waist Circumference
- From:Intestinal Research 2018;16(3):436-444
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Bone mineral density (BMD) is often low in patients with Crohn's disease (CD). This study aimed to evaluate the association between nutritional factors and BMD in a group of CD patients. METHODS: CD patients 18 years of age or older were included. The body mass index (BMI), waist circumference (WC) and dietary intake were evaluated during two 24-hour recalls. Bone densitometry was performed by dual-energy X-ray absorptiometry of the full body to assess body composition and of the lumbar vertebrae and femoral neck to assess BMD. RESULTS: In the 60 patients evaluated, there was no association between BMD and disease activity or between BMD and disease duration. We observed moderate correlations between BMD in at least one of the evaluated sites and BMI, lean mass, WC, and protein, calcium, phosphorus and magnesium dietary intakes (P < 0.05). In the linear regression analysis for spinal BMD, only BMI and calcium dietary intake remained associated (P < 0.05). In the linear regression analysis for femoral BMD, WC and phosphorus intake continued to be significant in the final model, although they had low explanatory power for BMD (P < 0.05). CONCLUSIONS: The prevalence of low BMD was high in CD patients. BMI, WC, calcium and phosphorus dietary intake were positively correlated with BMD.
