Expression of Hepatocyte Growth Factor/c-met by RT-PCR in Meningiomas.
10.4132/KoreanJPathol.2011.45.5.463
- Author:
Na Rae KIM
1
;
Yang Seok CHAE
;
Weon Jeong LIM
;
Seong Jin CHO
Author Information
1. Department of Pathology, Gachon University Gil Hospital, Incheon, Korea.
- Publication Type:Original Article
- Keywords:
Hepatocyte growth factor;
c-met;
Meningioma;
Neoplasm recurrence, local;
Reverse transcription polymerase chain reaction
- MeSH:
Hepatocyte Growth Factor;
Hepatocytes;
Meningioma;
Neoplasm Recurrence, Local;
Oncogenes;
Polymerase Chain Reaction;
Protein-Tyrosine Kinases;
Proto-Oncogene Proteins c-met;
Recurrence;
Reverse Transcription;
RNA, Messenger
- From:Korean Journal of Pathology
2011;45(5):463-468
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Hepatocyte growth factor (HGF) is a potent mitogenic cytokine. C-met protein, which is known to be the HGF receptor has transmembrane tyrosine kinase activity and is encoded by the c-met oncogene. The HGF/c-met signaling pathway may play various roles in the carcinogenesis of various organs. METHODS: We examined HGF and c-met mRNA expression by utilizing reverse transcription polymerase chain reaction on 40 surgically resected intracranial meningiomas (25 benign, 10 atypical, and 5 anaplastic cases). RESULTS: An HGF overexpression was detected in 28%, 50%, and 80% of the benign, atypical and anaplastic meningiomas, respectively; a high expression of HGF or the coexpression of HGF/c-met was detected in the high grade meningiomas (the atypical and anaplastic cases, p=0.046, p=0.014). An HGF expression was statistically significant in the recurrent meningiomas (p=0.003), and HGF expression was significantly lower than c-met mRNA expression in benign meningiomas (p=0.034). CONCLUSIONS: There was no correlation between histologic subtypes and HGF/c-met expression. Determination of HGF expression can be used as a molecular predictor for recurrence of meningioimas. These results suggest that HGF and c-met expression in meningiomas may be associated with anaplastic progression.
