Fetoscopic laser photocoagulation for twin-to-twin transfusion syndrome treatment: initial experience in tertiary reference center in Brazil.
10.5468/ogs.2018.61.4.461
- Author:
Maurício Mendes BARBOSA
1
;
Eduardo Félix MARTINS SANTANA
;
Hérbene José Figuinha MILANI
;
Julio ELITO JÚNIOR
;
Edward ARAUJO JÚNIOR
;
Antônio Fernandes MORON
;
Luciano Marcondes Machado NARDOZZA
Author Information
1. Department of Obstetrics, Paulista School of Medicine, São Paulo Federal University (EPM-UNIFESP), São Paulo, SP, Brazil. araujojred@terra.com.br
- Publication Type:Original Article
- Keywords:
Twin-to-twin transfusion syndrome;
Fetoscopy;
Lasers;
Perinatal mortalities
- MeSH:
Blood Vessels;
Brazil*;
Classification;
Female;
Fetofetal Transfusion*;
Fetoscopy;
Fetus;
Gestational Age;
Hemorrhage;
Humans;
Incidence;
Infant, Newborn;
Learning Curve;
Light Coagulation*;
Membranes;
Mortality;
Observational Study;
Operative Time;
Parturition;
Perinatal Mortality;
Pregnancy;
Pregnant Women;
Prospective Studies;
Referral and Consultation;
Rupture;
Tissue Donors
- From:Obstetrics & Gynecology Science
2018;61(4):461-467
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To evaluate the initial maternal and perinatal outcomes of fetoscopic laser photocoagulation for the treatment of twin-to-twin transfusion syndrome (TTTS) in a referral center in Brazil. METHODS: This prospective observational study analyzed 24 fetoscopic laser photocoagulation procedures at 18–26 weeks of gestation. TTTS severity was determined using the Quintero classification. Blood vessels that crossed the interamniotic membrane were nonselectively photocoagulated. The χ2 test and Mann-Whitney U test were used for the statistical analysis. RESULTS: The mean (±standard deviation) age of pregnant women, gestational age at surgery, surgical time, gestational age at birth, and newborn weight were 32.2±4.1 years, 20.7±2.9 weeks, 51.8±16.7 minutes, 30.5±4.1 weeks, and 1,531.0±773.1 g, respectively. Using the Quintero classification, there was a higher percentage of cases in stage III (54.2%), followed by stages IV (20.8%), II (16.7%), and I (8.3%). Ten (41.7%) donor fetuses died and 14 (58.3%) donor fetuses survived until the end of gestation. Placental insertion location (anterior vs. posterior) did not affect the incidence of iatrogenic septostomy, surface bleeding, and premature rupture of membranes until the end of gestation. The death rate of donor and recipient fetuses before 24th gestational week increased with severity of TTTS. CONCLUSION: The maternal and perinatal outcomes resulting from the implementation of a new minimally invasive surgical technique are in line with those obtained in major centers worldwide, considering the learning curves and infrastructures.
