Galectin-3 Reflects the Echocardiographic Grades of Left Ventricular Diastolic Dysfunction.
10.3343/alm.2018.38.4.306
- Author:
Uzair ANSARI
1
;
Michael BEHNES
;
Julia HOFFMANN
;
Michele NATALE
;
Christian FASTNER
;
Ibrahim EL-BATTRAWY
;
Jonas RUSNAK
;
Seung Hyun KIM
;
Siegfried LANG
;
Ursula HOFFMANN
;
Thomas BERTSCH
;
Martin BORGGREFE
;
Ibrahim AKIN
Author Information
1. First Department of Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany: DZHK (German Center for Cardiovascular Research) partner site Mannheim. uzair.ansari@umm.de
- Publication Type:Original Article
- Keywords:
Galectin-3;
Preserved ejection fraction;
NT-proBNP;
Diastolic dysfunction
- MeSH:
Classification;
Diagnosis;
Echocardiography*;
Galectin 3*;
Heart Failure;
Humans;
Prospective Studies;
ROC Curve;
Ventricular Remodeling
- From:Annals of Laboratory Medicine
2018;38(4):306-315
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The level of Galectin-3 (Gal-3) protein purportedly reflects an ongoing cardiac fibrotic process and has been associated with ventricular remodeling, which is instrumental in the development of heart failure with preserved ejection fraction (HFpEF) syndrome. The aim of this study was to investigate the potential use of Gal-3 in improved characterization of the grades of diastolic dysfunction as defined by echocardiography. METHODS: Seventy HFpEF patients undergoing routine echocardiography were prospectively enrolled in the present monocentric study. Blood samples for measurements of Gal-3 and amino-terminal pro-brain natriuretic peptide (NT-proBNP) were collected within 24 hours pre- or post-echocardiographic examination. The classification of patients into subgroups based on diastolic dysfunction grade permitted detailed statistical analyses of the derived data. RESULTS: The Gal-3 serum levels of all patients corresponded to echocardiographic indices, suggesting HFpEF (E/A, P=0.03 and E/E', P=0.02). Gal-3 was also associated with progressive diastolic dysfunction, and increased levels corresponded to the course of disease (P=0.012). Detailed analyses of ROC curves suggested that Gal-3 levels could discriminate patients with grade III diastolic dysfunction (area under the curve [AUC]=0.770, P=0.005). CONCLUSIONS: Gal-3 demonstrates remarkable effectiveness in the diagnosis of patients suffering from severe grade diastolic dysfunction. Increasing levels of Gal-3 possibly reflect the progressive course of HFpEF, as classified by the echocardiographic grades of diastolic dysfunction.
