The relationship between anti-C-reactive protein and disease activity in patients with systemic lupus erythematosus.
- Author:
Chang Nam SON
1
;
Tae Han LEE
;
Ji Hye BANG
;
Hye Jin JEONG
;
Jin Nyeong CHAE
;
Won Mok LEE
;
Ji Min KIM
;
Sang Hyon KIM
Author Information
- Publication Type:Original Article
- Keywords: Systemic lupus erythematosus; Anti-C-reactive protein antibody
- MeSH: Antibodies; Biomarkers; Complement System Proteins; DNA; Humans; Lupus Erythematosus, Systemic*
- From:The Korean Journal of Internal Medicine 2018;33(4):823-828
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Anti-C-reactive protein (CRP) antibody has been introduced as a potential biologic marker in Systemic lupus erythematosus (SLE). The aim of study is to evaluate the level of anti-CRP antibody in patients with SLE. METHODS: This study investigated the relationship between levels of anti-CRP antibodies and disease activity markers, such as complement, anti-double-stranded DNA antibody, and SLE disease activity index in 34 patients with SLE. RESULTS: The serum anti-CRP antibody levels of the patients with SLE were significantly higher than those of the healthy controls (11.3 ± 5.6 µg/mL vs. 9.1 ± 2.8 µg/mL). The percentages of the positive anti-CRP antibody were 52.9% in SLE and 27.8% in controls. Disease duration of SLE showed significant correlation with the anti-CRP antibody (r = 0.234, p = 0.026). However no significant relationship was observed between the levels of anti-CRP antibodies and disease activity markers. CONCLUSIONS: These data show that the anti-CRP antibody levels of the patients with SLE were significantly higher than those of healthy controls. We observed that the presence of the anti-CRP anti-CRP antibody was not associated with disease activity of SLE.
