Diagnosis of Liver Fibrosis With Wisteria floribunda Agglutinin-Positive Mac-2 Binding Protein (WFA-M2BP) Among Chronic Hepatitis B Patients.
10.3343/alm.2018.38.4.348
- Author:
Dong Wook JEKARL
1
;
Hyunyu CHOI
;
Seungok LEE
;
Jung Hyun KWON
;
Sung Won LEE
;
Hein YU
;
Myungshin KIM
;
Yonggoo KIM
;
Pil Soo SUNG
;
Seung Kew YOON
Author Information
1. Department of Laboratory Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Liver Fibrosis;
Hepatitis B;
Wisteria floribunda agglutinin-positive Mac-2 binding protein;
Diagnosis;
Efficacy
- MeSH:
Area Under Curve;
Aspartate Aminotransferases;
Biomarkers;
Biopsy;
Carrier Proteins*;
Diagnosis*;
Elasticity Imaging Techniques;
Fibrosis;
Glycosylation;
Hepacivirus;
Hepatitis B;
Hepatitis B virus;
Hepatitis B, Chronic*;
Hepatitis, Chronic*;
Humans;
Immunoassay;
Liver Cirrhosis*;
Liver*;
Multivariate Analysis;
Platelet Count;
ROC Curve;
Wisteria*
- From:Annals of Laboratory Medicine
2018;38(4):348-354
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA-M2BP) is a protein with altered glycosylation that reacts with lectin, and was recently identified as a useful non-invasive biomarker for the diagnosis of liver fibrosis in patients with hepatitis C virus infection.This study aimed to evaluate the diagnostic efficacy of WFA-M2BP for liver fibrosis in the context of hepatitis B virus (HBV). METHODS: We enrolled 151 patients infected with HBV. Liver biopsy and elastography (Fibroscan) were performed during the initial visit. Fibrosis was graded according to the Knodell histologic activity index (F0–3). WFA-M2BP levels were determined with an automated immunoassay analyzer (M2BPGi, HISCL-5000, Sysmex, Japan). The diagnostic efficacy of WFA-M2BP was compared with those of various conventional or composite biomarkers, including enhanced liver fibrosis (ELF) score, Fibroscan, aspartate transaminase (AST)-to-platelet ratio index (APRI), and FIB-4, based on the area under the ROC curve (AUC) value. RESULTS: The majority of patients were at fibrosis stages F1 and F2. The F2 and F3 AUC values for WFA-M2BP were similar to those for FIB-4, APRI, ELF, and Fibroscan, although the latter showed the best diagnostic efficacy. The diagnostic accuracy of all tested biomarkers for F2 and F3 was 60–70%. In multivariate analysis, WFA-M2BP, ELF, and platelet count significantly predicted stage ≥F2, whereas only platelet count significantly predicted F3. CONCLUSIONS: WFA-M2BP can support a diagnosis of liver fibrosis with similar diagnostic efficacy to other biomarkers, and predicted liver fibrosis stage ≥2 among patients with chronic hepatitis B.
