Effects of Aspirin, Nonsteroidal Anti-inflammatory Drugs, Statin, and COX2 Inhibitor on the Developments of Urological Malignancies: A Population-Based Study with 10-Year Follow-up Data in Korea.
- Author:
Minyong KANG
1
;
Ja Hyeon KU
;
Cheol KWAK
;
Hyeon Hoe KIM
;
Chang Wook JEONG
Author Information
- Publication Type:Original Article
- Keywords: National Health Insurance Corporation Database; Prostate neoplasms; Kidney neoplasms; Urothelial cancer; Anti-inflammatory agents
- MeSH: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin*; Cohort Studies; Cyclooxygenase 2; Follow-Up Studies*; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors*; Kidney; Kidney Neoplasms; Korea*; Multivariate Analysis; National Health Programs; Prostate; Prostatic Neoplasms
- From:Cancer Research and Treatment 2018;50(3):984-991
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: The purpose of this study was to determine the impact of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), statin, and cyclooxygenase 2 (COX-2) inhibitor on the development of kidney, prostate, and urothelial cancers by analyzing the Korean National Health Insurance Service–National Sample Cohort (NHIS-NSC) database. MATERIALS AND METHODS: Among a representative sample cohort of 1,025,340 participants in NHIS-NSC database in 2002, we extracted data of 799,850 individuals who visited the hospital more than once, and finally included 321,122 individuals aged 40 and older. Following a 1-year washout period between 2002 and 2003, we analyzed 143,870 (male), 320,861 and 320,613 individuals for evaluating the risk of prostate cancer, kidney cancer and urothelial cancer developments, respectively, during 10-year follow-up periods between 2004 and 2013. The medication group consisted of patients prescribed these drugs more than 60% of the time in 2003. To adjustfor various parameters of the patients, a multivariate Cox regression model was adopted. RESULTS: During 10-year follow-up periods between 2004 and 2013, 9,627 (6.7%), 1,107 (0.4%), and 2,121 (0.7%) patients were diagnosed with prostate cancer, kidney cancer, and urothelial cancer, respectively. Notably, multivariate analyses revealed that NSAIDs significantly increased the risk of prostate cancer (hazard ratio [HR], 1.35). Also, it was found that aspirin (HR, 1.28) and statin (HR, 1.55) elevated the risk of kidney cancer. No drugs were associated with the risk of urothelial cancer. CONCLUSION: In sum, our study provides the valuable information for the impact of aspirin, NSAID, statin, and COX-2 inhibitor on the risk of prostate, kidney, and urothelial cancer development and its survival outcomes.
