Higher Prevalence of Hypertension among Individuals with Restless Legs Syndrome: A Meta-Analysis.
- Author:
In Cheol HWANG
1
;
Kyoung Sae NA
;
Yu Jin LEE
;
Seung Gul KANG
Author Information
- Publication Type:Meta-Analysis ; Original Article
- Keywords: Restless legs syndrome; Hypertension; Prevalence; Meta-analysis
- MeSH: Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus; Dyslipidemias; Humans; Hypertension*; Incidence; Odds Ratio; Outcome Assessment (Health Care); Prevalence*; Prospective Studies; Restless Legs Syndrome*; Risk Factors
- From:Psychiatry Investigation 2018;15(7):701-709
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: This study investigated the proposed association between restless legs syndrome (RLS) and the prevalence of hypertension. METHODS: A meta-analysis was conducted based on searches of the PUBMED, EMBASE, Cochrane Library, and Korean electronic databases. Cohort and cross-sectional studies reporting the incidence of hypertension in individuals with RLS were included. Dichotomous data were pooled to obtain an odds ratio (OR) and 95% confidence interval (CI) for the prevalence of hypertension in individuals with RLS. The main outcome measure of the study was prevalence of hypertension in patients with RLS compared with a control group. RESULTS: One cohort study and eight cross-sectional studies were included in the meta-analysis. Individuals with RLS had an increased prevalence of hypertension (all studies: OR=1.13, 95% CI=1.04–1.23; cross-sectional studies: OR=1.12, 95% CI=1.01–1.24). However, in subgroup analyses controlling for cardiovascular risk factors, such as diabetes mellitus and dyslipidemia, the differences in the prevalence of hypertension between RLS and control patients were no longer significant. CONCLUSION: Patients with RLS may have a higher prevalence of hypertension, according to a pooled analysis, but the results remain to be confirmed in well-designed prospective studies.
