Relationship Between Serum Uric Acid Level and Metabolic Syndrome According to Gender.
10.4070/kcj.2008.38.3.152
- Author:
Seung Pyo HONG
1
;
Young Soo LEE
;
Kyung Ryun BAE
;
Jin Wook CHUNG
;
So Yeon KIM
;
Jin Bae LEE
;
Jae Kean RYU
;
Ji Yong CHOI
;
Kee Sik KIM
;
Sung Gug CHANG
;
Im Hee SHIN
Author Information
1. Department of Cardiology, Catholic University of Daegu College of Medicine, Daegu, Korea. mdleeys@ cu.ac.kr
- Publication Type:Original Article
- Keywords:
Uric acid;
Metabolic syndrome;
Gender
- MeSH:
Atherosclerosis;
Blood Glucose;
Body Mass Index;
Cholesterol;
Fasting;
Female;
Glucose;
Humans;
Hypertension;
Hyperuricemia;
Incidence;
Lipoproteins;
Male;
Mass Screening;
Risk Factors;
Uric Acid
- From:Korean Circulation Journal
2008;38(3):152-160
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Hyperuricemia is known to be a risk factor for atherosclerosis, as is gender. The variables related to metabolic syndrome (MS), as well as other cardiovascular risk factors such as serum uric acid (SUA), differ according to gender. The aim of this study was to evaluate the relationship between SUA and the variables of MS according to gender. SUBJECTS AND METHODS: We randomly recruited 675 subjects (373 men and 302 women), who underwent health screening. The subjects were divided into four groups according to SUA quartiles. We compared each quartile of the SUA with the incidence of MS. The variables included body mass index (BMI), hypertension, fasting blood glucose (FBS), high-density lipoprotein (HDL) cholesterol, triglyceride (TG), and the MS score. RESULTS: The incidence of MS in men was significantly increased compared to women, and the incidence of MS was increased according to the SUA values in women. The MS scores tended to increase according to the SUA values in both genders. The incidence of high BMI, high blood pressure, and high TG were correlated with the SUA values in both genders. However, HDL-cholesterol was correlated with MS scores in women, and fasting glucose was not correlated with MS in either gender. CONCLUSION: The variables of the MS might be independently associated with SUA values in both genders. In addition, the incidence of MS in women might be significantly increased according to the SUA values. However, large scale follow-up studies will be required to confirm these possibilities.
