Decreased IL-1ra and NCAM-1/CD56 Serum Levels in Unmedicated Patients with Schizophrenia Before and After Antipsychotic Treatment.
- Author:
Che Sheng CHU
1
;
Dian Jeng LI
;
Chin Liang CHU
;
Chih Ching WU
;
Ti LU
Author Information
- Publication Type:Original Article
- Keywords: Antipsychotic; Cytokines; Schizophrenia
- MeSH: Antipsychotic Agents; Brain-Derived Neurotrophic Factor; Brief Psychiatric Rating Scale; Carrier Proteins; Cytokines; Humans; Insulin; Interferon-gamma; Interleukin 1 Receptor Antagonist Protein*; Interleukin-1; Interleukin-6; Neural Cell Adhesion Molecules; Schizophrenia*
- From:Psychiatry Investigation 2018;15(7):727-732
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: Schizophrenia (SZ) has been associated with the inflammatory-related and immunological pathogenesis. This study investigates the aberration of cytokines in patients with SZ. METHODS: Thirty patients with SZ without antipsychotic treatment for at least two weeks participated. We measured the serum levels of fourteen cytokines at hospital admission and after 8-week antipsychotic treatment. Severity was measured by expanded version of 24-items brief psychiatric rating scale (BPRS-E). Repeated measure analyses of variance were conducted. RESULTS: The interleukin-1 receptor antagonist (IL-1ra) was significantly decreased after 8-week antipsychotic treatment than those of before antipsychotic treatment (F=12.15, df=1/30, p=0.002). Neural cell adhesion molecule 1/CD56 (NCAM-1/CD56) was significantly decreased (F=6.61, df=1/30, p=0.016) among those with second-generation antipsychotics but not first-generation antipsychotics treatment. The changes of BPRS-E-manic and BPRS-E-anxiety scores correlated with the baseline IL-1ra (r=-0.393), IL-6 (r=-0.407), and insulin like growth factor binding protein 3 (r=-0.446). Additionally, the changes of BPRS-E and BPRS-E-negative scores correlated with the changes of brain-derived neurotrophic factor (r=0.372) and interferon-gamma (r=0.375). CONCLUSION: Our study supports that IL-1ra and NCAM-1/CD56 may be considered as markers of developing SZ.
