Incidence and Associated Factor of Adverse Events of Tigecycline Therapy in Korean Patients.
- Author:
In Tae SO
1
;
Ji Yeon LEE
;
Miri HYUN
;
Hyun Ah KIM
;
Seong Yeol RYU
Author Information
1. Division of Infectious Disease, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea. 121rsy@dsmc.or.kr
- Publication Type:Meta-Analysis ; Original Article
- Keywords:
Adverse drug reaction;
Multiple-drug resistance;
Tigecycline
- MeSH:
Bacteria;
Compliance;
Drug-Related Side Effects and Adverse Reactions;
Humans;
Incidence*;
Intraabdominal Infections;
Nausea;
Retrospective Studies;
Skin;
Soft Tissue Infections;
Soft Tissue Injuries;
Vomiting
- From:Keimyung Medical Journal
2018;37(1):1-8
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Tigecycline is a broad spectrum antibiotic which has been used for complicated intra-abdominal infection and complicated skin and soft tissue infection by multi-drug resistant bacteria. However recent meta-analysis studies have raised a concern for adverse events of tigecycline. We analyzed retrospectively adverse events, associated factors of adverse events in multi-drug resistant bacteria caused infections treated with tigecycline in Korean patients. One hundred-sixty patients treated with tigecycline from July 2009 to September 2013 were enrolled in this study. Their clinical and microbiologic data were reviewed. History of invasive procedure within 7 days and recent operation within 3 months were associated with adverse events. The most common adverse events were nausea and vomiting. Associated factors of nausea were soft tissue injury and recent operation within 3 months. In this study, nausea was the most common adverse event in patients who received tigecycline. Although it is not serious complication, monitoring of adverse events is required to increase compliance.
