Single-Dose Gadoterate Meglumine for 3T Late Gadolinium Enhancement MRI for the Assessment of Chronic Myocardial Infarction: Intra-Individual Comparison with Conventional Double-Dose 1.5T MRI.
10.3348/kjr.2018.19.3.372
- Author:
Jiyeon LIM
1
;
Eun Ah PARK
;
Yong Sub SONG
;
Whal LEE
Author Information
1. Department of Radiology, Seoul National University Hospital, Seoul 03080, Korea. iameuna1@gmail.com
- Publication Type:Original Article
- Keywords:
Chronic myocardial infarction;
Magnetic resonance imaging;
Gadolinium contrast agent;
Late gadolinium enhancement
- MeSH:
Gadolinium*;
Humans;
Magnetic Resonance Imaging*;
Meglumine*;
Myocardial Infarction*;
Myocardium
- From:Korean Journal of Radiology
2018;19(3):372-380
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To intra-individually compare 3T magnetic resonance (MR) images obtained with one dose gadoterate meglumine to 1.5T MR using conventional double dose for assessment of chronic myocardial infarction. MATERIALS AND METHODS: Sixteen patients diagnosed with chronic myocardial infarctions were examined on single-dose 3T MR within two weeks after undergoing double-dose 1.5T MR. Representative short-axis images were acquired at three points after administration of gadoterate meglumine. Contrast-to-noise ratios between infarcted and normal myocardium (CNRinfarct-normal) and between infarct and left ventricular cavity (CNRinfarct-LVC) were calculated and compared intra-individually at each temporal scan. Additionally, two independent readers assessed relative infarct size semi-automatically and inter-observer reproducibility was evaluated using intraclass correlation coefficient. RESULTS: While higher CNRinfarct-normal was revealed at single-dose 3T at only 10 minutes scan (p = 0.047), the CNRinfarct-LVC was higher at single-dose 3T MR at each temporal scan (all, p < 0.05). Measurement of relative infarct size was not significantly different between both examinations for both observers (all, p > 0.05). However, inter-observer reproducibility was higher at single-dose 3T MR (all, p < 0.05). CONCLUSION: Single-dose 3T MR is as effective as double-dose 1.5T MR for delineation of infarcted myocardium while being superior in detection of infarcted myocardium from the blood cavity, and provides better reproducibility for infarct size quantification.
