The Impact of Prediabetes on Two-Year Clinical Outcomes in Patients Undergoing Elective Percutaneous Coronary Intervention.
10.3349/ymj.2018.59.4.489
- Author:
Woong gil CHOI
1
;
Seung Woon RHA
;
Byoung Geol CHOI
;
Se Yeon CHOI
;
Jae Kyeong BYUN
;
Ahmed MASHALY
;
Yoonjee PARK
;
Won Young JANG
;
Woohyeun KIM
;
Jah Yeon CHOI
;
Eun Jin PARK
;
Jin Oh NA
;
Cheol Ung CHOI
;
Eung Ju KIM
;
Chang Gyu PARK
;
Hong Seog SEO
Author Information
1. Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea. swrha617@yahoo.co.kr
- Publication Type:Original Article
- Keywords:
Hemoglobin A1c;
prediabetes;
percutaneous coronary intervention;
drug-eluting stent
- MeSH:
Cardiovascular Diseases;
Drug-Eluting Stents;
Follow-Up Studies;
Glucose;
Humans;
Incidence;
Mortality;
Percutaneous Coronary Intervention*;
Prediabetic State*;
Risk Factors
- From:Yonsei Medical Journal
2018;59(4):489-494
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Prediabetes is an independent risk factor for cardiovascular disease. However, data on the long term adverse clinical outcomes of prediabetic patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DESs) are scarce. MATERIALS AND METHODS: The study population comprised 674 consecutive non-diabetic patients who underwent elective PCI between April 2007 and November 2010. Prediabetes was defined as hemoglobin A1c (HbA1c) of 5.7% to 6.4%. Two-year cumulative clinical outcomes of prediabetic patients (HbA1c of 5.7% to 6.4%, n=242) were compared with those of a normoglycemic group (< 5.7%, n=432). RESULTS: Baseline clinical and angiographic characteristics were similar between the two groups, except for higher glucose levels (104.8±51.27 mg/dL vs. 131.0±47.22 mg/dL, p < 0.001) on admission in the prediabetes group. There was no significant difference between the two groups in coronary angiographic parameters, except for a higher incidence of diffuse long lesion in the prediabetes group. For prediabetic patients, trends toward higher incidences of binary restenosis (15.6% vs. 9.8 %, p=0.066) and late loss (0.71±0.70 mm vs. 0.59±0.62 mm, p=0.076) were noted. During the 24 months of follow up, the incidence of mortality in prediabetic patients was higher than that in normoglycemic patients (5.5% vs. 1.5%, p=0.007). CONCLUSION: In our study, a higher death rate and a trend toward a higher incidence of restenosis in patients with prediabetes up to 2 years, compared to those in normoglycemic patients, undergoing elective PCI with contemporary DESs.
