Clinical Analysis of Drug Eruptions among Inpatients Seeking a Consultation with the Department of Dermatology.
- Author:
Min Young LEE
1
;
Ji Yeon BYUN
;
Hae Young CHOI
;
You Won CHOI
Author Information
1. Department of Dermatology, Ewha Womans University College of Medicine, Seoul, Korea. uwon313@ewha.ac.kr
- Publication Type:Original Article
- Keywords:
Cutaneous adverse drug reaction;
Dermatological consultation;
Drug eruption;
Drug rash
- MeSH:
Acneiform Eruptions;
Anti-Bacterial Agents;
Antineoplastic Agents;
Contrast Media;
Creatinine;
Dermatology*;
Diagnosis;
Drug Eruptions*;
Drug-Related Side Effects and Adverse Reactions;
Eosinophilia;
Humans;
Incidence;
Inpatients*;
Leukocytosis;
Leukopenia;
Liver Function Tests;
Referral and Consultation;
Retrospective Studies;
Urticaria
- From:Korean Journal of Dermatology
2018;56(5):314-321
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Drug eruptions are common in hospitalized patients. Rapid and accurate diagnosis is essential but often difficult. OBJECTIVE: This study defined the clinical features and causative drugs among inpatients presenting with drug eruptions. METHODS: We retrospectively analyzed the clinical and laboratory data of inpatients who sought consultations with the Dermatology Department for a diagnosis of drug eruptions. RESULTS: A total of 228 patients were diagnosed with drug eruptions, and this study included 139 patients. The highest incidence of drug eruptions was observed in patients in their 50s (22.3%). The most common latent period was up to 1 week (57.6%). The most common drug eruptions were exanthematous eruptions (59.7%), acneiform eruptions (10.8%), and urticaria (9.3%). The most common causative drugs were antibiotics (53.2%), followed by anticancer drugs (19.4%), and contrast media (6.5%). Laboratory abnormalities included eosinophilia (15.8%), abnormal liver function tests (7.9%), leukopenia (4.3%), an elevated serum creatinine level (2.2%), and leukocytosis (0.7%). CONCLUSION: In descending order, the most frequent drug eruptions were exanthematous eruptions, acneiform eruptions, and urticaria, and the most common causative drugs were antibiotics, anticancer agents, and contrast media. Prompt diagnosis and discontinuation of the causative drug are important in this context. Clinicians should be aware of cutaneous adverse drug reactions.
