Elevation of Morning Blood Pressure in Sodium Resistant Subjects by High Sodium Diet.
10.3346/jkms.2013.28.4.555
- Author:
Moo Yong RHEE
1
;
Chi Yeon LIM
;
Sung Joon SHIN
;
Sang Woo OH
;
Yong Soon PARK
;
Jong Wook KIM
;
Hye Kyoung PARK
;
Cho Il KIM
;
Cheol Young PARK
;
Sun Woong KIM
Author Information
1. Cardiovascular Center, Dongguk University Ilsan Hospital, Goyang, Korea. mooyong_rhee@dumc.or.kr
- Publication Type:Original Article ; Evaluation Studies ; Research Support, Non-U.S. Gov't
- Keywords:
Sodium;
Hypertension;
Sodium Resistance
- MeSH:
Adult;
Blood Pressure/*drug effects;
Diet, Sodium-Restricted;
Humans;
Hypertension/*physiopathology;
Middle Aged;
Sodium, Dietary/*pharmacology;
Time Factors
- From:Journal of Korean Medical Science
2013;28(4):555-563
- CountryRepublic of Korea
- Language:English
-
Abstract:
The present study evaluated the response of blood pressure (BP) by dietary sodium in sodium resistant (SR) subjects. One hundred one subjects (mean age, 46.0 yr; 31 hypertensives) were admitted and given low sodium-dietary approaches to stop hypertension (DASH) diet (LSD, 100 mM NaCl/day) for 7 days and high sodium-DASH diet (HSD, 300 mM NaCl/day) for the following 7 days. On the last day of each diet, 24 hr ambulatory BP was measured. Morning systolic BP (SBP) and diastolic BP (DBP) were elevated after HSD in all subjects (P < 0.01), but daytime SBP and DBP were not changed (P > 0.05). In hypertensive subjects, morning DBP elevation was greater than daytime DBP elevation (P = 0.036), although both DBPs were significantly elevated after HSD. The augmented elevation of morning DBP in hypertensive subjects was contributed by the absolute elevation of morning DBP (P = 0.032) and relative elevation to daytime DBP (P = 0.005) in sodium resistant (SR) subjects, but not by sodium sensitive subjects. Although there was no absolute elevation, SR subjects with normotension showed a relative elevation of morning SBP compared to daytime SBP change after HSD (P = 0.009). The present study demonstrates an absolute and relative elevation of morning BP in SR subjects by HSD.
