Samter's Triad: State of the Art.

Author: Sung Dong KIM ¹ ; Kyu Sup CHO
Author Information

1. Department of Otorhinolaryngology-Head and Neck Surgery and Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea. choks@pusan.ac.kr
Publication Type:Review
Keywords: Aspirin; Asthma; Nasal Polyps; Sinusitis; Desensitization; Physiopathology
MeSH: Aspirin; Asthma; Diagnosis; Genetic Background; Nasal Polyps; Sinusitis
From:Clinical and Experimental Otorhinolaryngology 2018;11(2):71-80
CountryRepublic of Korea
Language:English
Abstract: Samter's triad (ST) is a well-known disease characterized by the triad of bronchial asthma, nasal polyps, and aspirin intolerance. Over the past few years, a rapid development in the knowledge of the pathogenesis and clinical characteristics of ST has happened. The aim of this paper is to review the recent investigations on the pathophysiological mechanisms and genetic background, diagnosis, and different therapeutic options of ST to advance our understanding of the mechanism and the therapeutic control of ST. As concern for ST increase, more application of aspirin desensitization will be required to manage this disease successfully. There is also a need for continued research efforts in pathophysiology, treatment, and possible prevention.