Nodule Classification on Low-Dose Unenhanced CT and Standard-Dose Enhanced CT: Inter-Protocol Agreement and Analysis of Interchangeability.
10.3348/kjr.2018.19.3.516
- 作者:
Kyung Hee LEE
1
;
Kyung Won LEE
;
Ji Hoon PARK
;
Kyunghwa HAN
;
Jihang KIM
;
Sang Min LEE
;
Chang Min PARK
作者信息
1. Department of Radiology, Seoul National University Bundang Hospital, Seongnam 13620, Korea. lkwrad@gmail.com
- 出版类型:Original Article
- 关键字:
Pulmonary nodules;
Classification;
Subsolid nodule;
Ground-glass nodule;
Computed tomography;
Low-dose CT
- 医学主题词:
Classification*;
Humans;
Tomography, X-Ray Computed
- 来源:Korean Journal of Radiology
2018;19(3):516-525
- 国家Republic of Korea
- 语言:English
-
摘要:
OBJECTIVE: To measure inter-protocol agreement and analyze interchangeability on nodule classification between low-dose unenhanced CT and standard-dose enhanced CT. MATERIALS AND METHODS: From nodule libraries containing both low-dose unenhanced and standard-dose enhanced CT, 80 solid and 80 subsolid (40 part-solid, 40 non-solid) nodules of 135 patients were selected. Five thoracic radiologists categorized each nodule into solid, part-solid or non-solid. Inter-protocol agreement between low-dose unenhanced and standard-dose enhanced images was measured by pooling κ values for classification into two (solid, subsolid) and three (solid, part-solid, non-solid) categories. Interchangeability between low-dose unenhanced and standard-dose enhanced CT for the classification into two categories was assessed using a pre-defined equivalence limit of 8 percent. RESULTS: Inter-protocol agreement for the classification into two categories {κ, 0.96 (95% confidence interval [CI], 0.94–0.98)} and that into three categories (κ, 0.88 [95% CI, 0.85–0.92]) was considerably high. The probability of agreement between readers with standard-dose enhanced CT was 95.6% (95% CI, 94.5–96.6%), and that between low-dose unenhanced and standard–dose enhanced CT was 95.4% (95% CI, 94.7–96.0%). The difference between the two proportions was 0.25% (95% CI, −0.85–1.5%), wherein the upper bound CI was markedly below 8 percent. CONCLUSION: Inter-protocol agreement for nodule classification was considerably high. Low-dose unenhanced CT can be used interchangeably with standard-dose enhanced CT for nodule classification.
