A Concomitant Hemato-Oncologic Disorder of Patient with Down Syndrome.
- Author:
Kyeong Bae PARK
1
;
Dong Hwan LEE
Author Information
1. Department of Pediatrics, Soonchunhyang University College of Medicine, Cheonan, Korea. kbpark@schmc.ac.kr
- Publication Type:Review
- Keywords:
Down syndrome;
Lymphoblastic leukemia;
Acute myeloid leukemia;
Myeloproliferative disorders
- MeSH:
Anemia, Aplastic;
Blood Platelets;
Chromosomes, Human, Pair 21;
Down Syndrome*;
Erythrocytes;
Hemorrhage;
Humans;
Leukemia, Myeloid, Acute;
Leukocytes;
Life Expectancy;
Myeloproliferative Disorders;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
Quality of Life;
Wilms Tumor
- From:Soonchunhyang Medical Science
2018;24(1):1-7
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A patient with Down syndrome has hematologic and oncologic disorders of medical complication. Down syndrome shows that characteristic hematologic and oncologic abnormalities and developments of disorders are different at ages. Many hematologic disorders were related to Down syndrome. There are diseases of red blood cells, white blood cell disorders, platelet and bleeding disorders, aplastic anemia, and transient myeloproliferative disease. Acute myeloid leukemia, acute lymphoblastic leukemia, and rarely solid tumors (Neuroblastoma, Wilm's tumor, Hodgkin's lymphoma) are also associated with Down syndrome. We checked clinical manifestations of each disorder and we should make standard hematologic index of different age groups. In addition, the relations between chromosome 21 and hemato-oncologic disorders should be found. We need to investigate potential therapeutic interventions that can improve quality of life and life expectancy in patients with Down syndrome.
