Multiple Markers of Contrast Induced Nephropathy after the Percutaneous Coronary Intervention.
- Author:
Byoung Won PARK
1
;
Seong Soon KWON
;
Min Ho LEE
;
Do Hoi KIM
;
Min Su HYON
;
Duk Won BANG
Author Information
1. Division of Cardiology, Department of Internal Medicine, Soonchunhyang University Hospital, Seoul, Korea. dukwon.bang@gmail.com
- Publication Type:Original Article
- Keywords:
Nephropathy;
Percutaneous coronary intervention;
Contrast media
- MeSH:
Catheterization;
Catheters;
Contrast Media;
Creatinine;
Cystatin C;
Humans;
Interleukin-18;
Kidney;
Neutrophils;
Percutaneous Coronary Intervention*
- From:Soonchunhyang Medical Science
2018;24(1):15-21
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Contrast-induced nephropathy (CIN) frequently occurs after percutaneous intervention. Objective of this study was to investigate the usefulness of serum cystatin C, neutrophil gelatinase-associated lipocalcin (NGAL), urinary kidney injury molecule-1 (KIM-1), and interleukin-18 (IL-18) as early predictors for CIN after percutaneous coronary intervention (PCI). METHODS: In 53 patients who underwent PCI were enrolled. Serum creatinine and cystatin C level were measured immediately before, and 24 hours and 48 hours after catheterization. Serum NGAL, urinary KIM-1, and IL-18 were measured immediately before, and 4 hours, 24 hours, and 48 hours after catheterization. CIN was defined as a rise in creatinine 0.5 mg/dL or 25% above baseline. RESULTS: CIN occurred in four patients (7.5%). Serum cystatin C levels were higher at 24 hours and 48 hours in CIN patients than in those without CIN (P<0.05). Serum NGAL levels were higher at 48 hours in CIN patients than in those without CIN. Urinary KIM-1 levels were higher at 48 hours in CIN patients than in those without CIN. There were no significant markers of CIN on multi-variate analysis. CONCLUSION: In this study, the occurrence of CIN after PCI was 7.5%. Although there were some time-course changes in serum cystatin C and urinary KIM-1 after PCI, there was no significant predictor for CIN after PCI.
