Two Cases of Neonatal Lupus and Literature Review.
- Author:
Dong Hyun KIM
1
;
Seung Ju LEE
;
Tae Ho KIM
;
Gyeong Hee YOO
;
Ji Yeon LEE
;
Sung Yul LEE
;
Sung Hae CHANG
;
Hyun Ju LEE
;
Soon Auck HONG
;
Joon Soo PARK
Author Information
1. Department of Pediatrics, Soonchunhyang University College of Medicine, Cheonan, Korea. pjstable@schmc.ac.kr
- Publication Type:Case Report
- Keywords:
Neonatal lupus;
Autoantibodies;
Exanthema
- MeSH:
Antibodies, Antinuclear;
Arthralgia;
Autoantibodies;
Biopsy;
Cheek;
Connective Tissue;
Connective Tissue Diseases;
Exanthema;
Female;
Fetus;
Hand;
Heart Block;
Hepatitis;
Humans;
Immunoglobulin G;
Infant;
Infant, Newborn;
Internal Medicine;
Lupus Erythematosus, Systemic;
Male;
Mothers;
Neutropenia;
Placenta;
Rheumatic Diseases;
Rheumatoid Factor;
Rheumatology;
Skin
- From:Soonchunhyang Medical Science
2018;24(1):76-80
- CountryRepublic of Korea
- Language:English
-
Abstract:
Neonatal lupus is a rare rheumatic disease. Clinical manifestations include characteristic annular or macular rashes, congenital heart block, cytopenias, and hepatitis. Neonatal lupus is caused by transmission of maternal immunoglobulin G autoantibodies such as anti-SSA/Ro antibody or anti-SSB/La antibody to the fetus through the placenta. We report two cases of neonatal lupus. The first case refers to an 18-day-old male with annular rashes on both cheeks, neutropenia, positive tests for antinuclear antibody, anti-SSA/Ro antibody, and anti-SSB/La antibody. His mother was diagnosed with systemic lupus erythematosus characterized by positive tests for antinuclear antibody, anti-SSA/Ro antibody, and anti-SSB/La antibody. The second case represents a 32-day-old female with annular rash on both hands, soles, and the genital area, neutropenia, hepatitis, positive tests for antinuclear antibody, and anti-SSA/Ro antibody. Skin punch biopsy was conducted. Her mother did not have history of connective tissue diseases. We referred her mother to the division of rheumatology of the department of internal medicine. The mother was suspected with primary Sjögren's syndrome because of arthralgia and dry eye symptoms with positive tests for antinuclear antibody, anti-SSA/Ro antibody, anti-SSB/La antibody, and rheumatoid factor. It is necessary to suspect neonatal lupus in neonates or infants with characteristic annular rash with or without maternal history of connective tissue disorders.
