Expression of collagenases (matrix metalloproteinase-1, 8, 13) and tissue inhibitor of metalloproteinase-1 of retrodiscal tissue in temporomandibular joint disorder patients.
10.5125/jkaoms.2018.44.3.120
- Author:
Won Gyung GHO
1
;
Yuri CHOI
;
Kwang Ho PARK
;
Jong Ki HUH
Author Information
1. Department of Dentistry, Myongji Hospital, Goyang, Korea.
- Publication Type:Original Article
- Keywords:
Collagenases;
Matrix metalloproteinase;
Tissue inhibitor of metalloproteinase;
Temporomandibular joint disorders;
Immunohistochemistry
- MeSH:
Collagenases*;
Diskectomy;
Humans;
Immunohistochemistry;
Joints;
Magnetic Resonance Imaging;
Matrix Metalloproteinases;
Osteoarthritis;
Temporomandibular Joint Disorders*;
Temporomandibular Joint*;
Tissue Inhibitor of Metalloproteinase-1*
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2018;44(3):120-127
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVES: The aim of this study was to reveal how collagenases (matrix metalloproteinase [MMP]-1, 8, 13) and tissue inhibitor of metalloproteinase 1 (TIMP-1) are expressed in immunohistochemistry of retrodiscal tissue in temporomandibular joint disorder patients. MATERIALS AND METHODS: This study was conducted on 39 patients who underwent discoplasty or discectomy. Immunohistochemical staining was undertaken and expression levels of MMP-1, 8, 13, and TIMP-1 were evaluated. The status of internal derangement of disc, osteoarthritis, and joint effusion were analyzed using magnetic resonance imaging (MRI). Disc status observed during operation was also categorized. RESULTS: The more severe disc derangement was observed on MRI, the more increased expression of MMPs and TIMP-1 appeared. Regarding MMP-13 expression, 86.7% of late-stage disc displacement patients showed grade II or III. Expression level of MMPs or TIMP was not statistically significant associated with joint effusion level. In perforation and/or adhesion groups, all patients showed grade II or III expression of MMP-13. Once perforation occurred, MMP-13 showed increased expression with statistical significance. CONCLUSION: MMP-1 and MMP-13 expression seem to be related to progression of osteoarthritis whereas MMP-8 does not seem to have a specific role with regard to temporomandibular joint disorders. TIMP-1 is considered to be partly related to internal derangement rather than osteoarthritis, but it is not significant.
