Effects of DA-5513 on alcohol metabolism and alcoholic fatty liver in rats.
- Author:
Jae Young YU
1
;
Hanh Thuy NGUYEN
;
Chul Soon YONG
;
Hyoung Geun PARK
;
Joon Ho JUN
;
Jong Oh KIM
Author Information
- Publication Type:Original Article
- Keywords: Morning care®; hangover; acetaldehyde; alcohol-induced fatty liver; hepatic triglyceride
- MeSH: Acetaldehyde; Alanine Transaminase; Alcohol Drinking; Alcoholics*; Animals; Aspartic Acid; Beverages; Cholesterol; Diet; Fatty Liver, Alcoholic*; Humans; Liver; Liver Diseases; Metabolism*; Rats*; Triglycerides
- From:Laboratory Animal Research 2018;34(2):49-57
- CountryRepublic of Korea
- Language:English
- Abstract: Hangover is characterized by a number of unpleasant physical and mental symptoms that occur after heavy alcohol drinking. In addition, consistently excessive alcohol intake is considered as a major reason causes liver disease. The present study investigated the in vivo effects of DA-5513 (Morning care® Kang Hwang) on biological parameters relevant to hangover relief and alcoholic fatty liver. Blood alcohol and acetaldehyde concentrations were determined in rats administered a single dose of alcohol and treated with DA-5513 or commercially available hangover relief beverages (Yeomyung® and Ukon®). The effects of DA-5513 on alcoholic fatty liver were also determined in rats fed alcohol-containing Lieber-DeCarli diets for 4 weeks. Serum liver function markers (aspartate and alanine aminotransferase activities) and serum/liver lipid levels were assessed. Blood alcohol and acetaldehyde concentrations were lower in the groups treated with DA-5513 or Yeomyung®, as compared with control rats. However, Ukon® did not produce any significant effects on these parameters. Treatment with DA-5513 significantly reduced serum aspartate and alanine aminotransferase activities and markedly reduced serum cholesterol and triglyceride levels, as compared with control rats. Histological observations using Oil Red O staining found that DA-5513 delayed the development of alcoholic fatty liver by reversing hepatic fat accumulation. These findings suggest that DA-5513 could have a beneficial effect on alcohol-induced hangovers and has the potential to ameliorate alcoholic fatty liver.
