Plasma CRABP2 as a Novel Biomarker in Patients with Non-Small Cell Lung Cancer.
10.3346/jkms.2018.33.e178
- Author:
Do Jun KIM
1
;
Woo Jin KIM
;
Myoungnam LIM
;
Yoonki HONG
;
Seung Joon LEE
;
Seok Ho HONG
;
Jeongwon HEO
;
Hui Young LEE
;
Seon Sook HAN
Author Information
1. Department of Internal Medicine, Kangwon National University Hospital, Chuncheon, Korea.
- Publication Type:Original Article
- Keywords:
Carcinoma;
Non-Small Cell Lung;
CRABP2;
Biological Marker
- MeSH:
Biomarkers;
Carcinoma, Non-Small-Cell Lung*;
Carrier Proteins;
Enzyme-Linked Immunosorbent Assay;
Genetic Markers;
Humans;
Korea;
Lung Diseases;
Lung Neoplasms;
Mortality;
Plasma*;
Smoking;
Survival Rate;
Tretinoin
- From:Journal of Korean Medical Science
2018;33(26):e178-
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Lung cancer is the most common cause of cancer-related mortality worldwide. We previously reported the identification of a new genetic marker, cellular retinoic acid binding protein 2 (CRABP2), in lung cancer tissues. The aim of this study was to assess plasma levels of CRABP2 from patients with non-small cell lung cancer (NSCLC). METHODS: Blood samples that were collected from 122 patients with NSCLC between September 2009 and September 2013 were selected for the analysis, along with samples from age- (± 5 years), sex-, and cigarette smoking history (± 10 pack-years [PY])-matched controls from the Korea Biobank Network. The control specimens were from patients who were without malignancies or pulmonary diseases. We measured plasma levels of CRABP2 using commercially available enzyme-linked immunosorbent assay kits. RESULTS: The mean age of the NSCLC patients was 71.8 ± 8.9 years, and the median cigarette smoking history was 32 PY (range, 0–150 PY). Plasma CRABP2 levels were significantly higher in patients with NSCLC than in the matched controls (37.63 ± 28.71 ng/mL vs. 24.09 ± 21.09 ng/mL, P < 0.001). Higher plasma CRABP2 levels were also correlated with lower survival rates in NSCLC patients (P = 0.014). CONCLUSION: Plasma CRABP2 levels might be a novel diagnostic and prognostic marker in NSCLC.
