Stem Cell Tracing Through MR Molecular Imaging.
10.1007/s13770-017-0112-8
- Author:
Rasoul YAHYAPOUR
1
;
Bagher FARHOOD
;
Ghazale GRAILY
;
Abolhasan REZAEYAN
;
Saeed REZAPOOR
;
Hamid ABDOLLAHI
;
Mohsen CHEKI
;
Peyman AMINI
;
Hengameh FALLAH
;
Masoud NAJAFI
;
Elahe MOTEVASELI
Author Information
1. School of Medicine, Jiroft University of Medical Sciences, Jiroft 8813833435, Iran.
- Publication Type:Clinical Trial ; Review
- Keywords:
Stem cell;
MRI;
Molecular imaging;
Regenerative medicine;
Cell therapy
- MeSH:
Brain Injuries;
Cartilage;
Cell- and Tissue-Based Therapy;
Contrast Media;
Fluorine;
Gadolinium;
Genes, Reporter;
Hope;
Magnetic Resonance Imaging;
Molecular Imaging*;
Multiple Sclerosis;
Nanoparticles;
Regenerative Medicine;
Stem Cell Transplantation;
Stem Cells*
- From:
Tissue Engineering and Regenerative Medicine
2018;15(3):249-261
- CountryRepublic of Korea
- Language:English
-
Abstract:
Stem cell therapy opens a new window in medicine to overcome several diseases that remain incurable. It appears such diseases as cardiovascular disorders, brain injury, multiple sclerosis, urinary system diseases, cartilage lesions and diabetes are curable with stem cell transplantation. However, some questions related to stem cell therapy have remained unanswered. Stem cell imaging allows approval of appropriated strategies such as selection of the type and dose of stem cell, and also mode of cell delivery before being tested in clinical trials. MRI as a non-invasive imaging modality provides proper conditions for this aim. So far, different contrast agents such as superparamagnetic or paramagnetic nanoparticles, ultrasmall superparamagnetic nanoparticles, fluorine, gadolinium and some types of reporter genes have been used for imaging of stem cells. The core subject of these studies is to investigate the survival and differentiation of stem cells, contrast agent's toxicity and long term following of transplanted cells. The promising results of in vivo and some clinical trial studies may raise hope for clinical stem cells imaging with MRI.
