Incidence Rate of Injection-Site Granulomas Resulting from the Administration of Luteinizing Hormone-Releasing Hormone Analogues for the Treatment of Prostatic Cancer.
10.3349/ymj.2007.48.3.421
- Author:
Masaki SHIOTA
1
;
Noriaki TOKUDA
;
Takehiro KANOU
;
Humio YAMASAKI
Author Information
1. Department of Urology, Saga Prefectural Hospital, Koseikan, Saga, Japan. shiota1976@yahoo.co.jp
- Publication Type:Case Reports
- Keywords:
Goserelin acetate;
granulomas;
LH-RH analogue;
leuprorelin acetate;
prostatic neoplasms
- MeSH:
Aged;
Aged, 80 and over;
Antigens, CD/analysis;
Antigens, CD3/analysis;
Antigens, Differentiation, Myelomonocytic/analysis;
Antineoplastic Agents, Hormonal/administration & dosage/adverse effects;
Gonadotropin-Releasing Hormone/administration & dosage/*adverse effects/analogs & derivatives;
Goserelin/administration & dosage/adverse effects;
Granuloma/*etiology/metabolism/pathology;
Humans;
Injections, Subcutaneous/adverse effects;
Leuprolide/administration & dosage/adverse effects;
Male;
Prostatic Neoplasms/*drug therapy
- From:Yonsei Medical Journal
2007;48(3):421-424
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Granulomas resulting from the administration of luteinizing hormone-releasing hormone analogues (LH-RH analogues) are thought to be very rare. We report on our clinical experience with injection-site granulomas that result from the administration of LH-RH analogues, and we evaluate the incidence rate of these granulomas. MATERIALS AND METHODS: We used the clinical records of 118 patients who were administered LH-RH analogues in 2005. We describe the clinical data of patients who experienced injection-site granulomas and evaluated the incidence rate. RESULTS: Five patients demonstrated injection-site granulomas due to LH-RH analogue administration. The incidence rate was 4.2% (5 of 118 patients). Most of the granulomas occurred after the first or second administration of 11.25mg of leuprorelin acetate. CONCLUSION: The occurrence of granulomas resulting from the administration of LH-RH analogues was thought to be very rare. Our study, however, revealed a higher incidence rate than expected, especially for leuprorelin acetate.
