Anti-obesity and LDL-cholesterol lowering effects of silkworm hemolymph in C57BL/6N mice fed high fat diet.
10.4163/jnh.2018.51.3.201
- Author:
You Ree NAM
1
;
Young Eun KO
;
Sun Yung LY
Author Information
1. Department of Food and Nutrition, Chungnam National University, Daejeon 34134, Korea. sunly@cnu.ac.kr
- Publication Type:Original Article
- Keywords:
silkworm hemolymph;
anti-obesity;
LDL-cholesterol lowering effect
- MeSH:
Animals;
Anti-Obesity Agents;
Body Weight;
Bombyx*;
Cardiovascular Diseases;
Diet, High-Fat*;
Hemolymph*;
Hyperlipidemias;
Hypertension;
Insulin;
Insulin Resistance;
Leptin;
Mice*;
Obesity;
Plasma;
Weights and Measures
- From:Journal of Nutrition and Health
2018;51(3):201-207
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Obesity, a worldwide epidemic, is associated with insulin resistance, hyperlipidemia, hypertension, cardiovascular disease, and certain cancers. Many strategies, including natural alternative anti-obesity agents, are used widely to prevent obesity. This study examined the effects of silkworm hemolymph on the weight control of C57BL/6N mice fed with a high-fat diet. METHODS: The mice were divided into five groups: normal group (N), high-fat diet group (HFC), high-fat diet and silkworm hemolymph (at dose of 1 mL/kg BW (HFS-1), 5 mL/kg BW (HFS-5) and 10 mL/kg (HFS-10) for 12 weeks. RESULTS: After 12 weeks treatment, the administration of silkworm hemolymph decreased the final body weight significantly along with a decrease in the weights of epididymal fat and total fat. The plasma LDL-cholesterol concentration was significantly lower in the HFS-1, HFS-5, and HFS-10 groups than in the HFC group. In addition, the leptin level of the HFS groups was significantly lower than those of the HFC group without a change in the plasma insulin concentration. CONCLUSION: These findings suggest that the silkworm hemolymph may have the potential to prevent obesity.
