Verification of a Western Nomogram for Predicting Oncotype DX™ Recurrence Scores in Korean Patients with Breast Cancer.
10.4048/jbc.2018.21.2.222
- Author:
Jae Myung KIM
1
;
Jai Min RYU
;
Isaac KIM
;
Hee Jun CHOI
;
Seok Jin NAM
;
Seok Won KIM
;
Jonghan YU
;
Se Kyung LEE
;
Jeong Eon LEE
Author Information
1. Department of Surgery, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.
- Publication Type:Brief Communication
- Keywords:
Breast neoplasms;
Ethnic groups;
Nomograms;
Recurrence
- MeSH:
Asia;
Breast Neoplasms*;
Breast*;
Dataset;
Ethnic Groups;
Humans;
Korea;
Nomograms*;
Recurrence*;
Tennessee
- From:Journal of Breast Cancer
2018;21(2):222-226
- CountryRepublic of Korea
- Language:English
-
Abstract:
A recent study conducted at the University of Tennessee Medical Center using a large dataset from the National Cancer Database (NCDB) reported the use of nomograms for predicting Oncotype DX™ (ODX) scores with clinicopathologic data. We reviewed the data of 218 patients who underwent the ODX test at a single institution in Korea to confirm that nomograms can accurately predict ODX score groups using our data, which differ from those of the NCDB in terms of ethnicity. The concordance index (c-index) of nomograms was much lower than that of the University of Tennessee Medical Center for high- and low-risk groups of commercial ODX and Trial Assigning Individualized Options for Treatment values. Although the nomogram for predicting ODX scores was based on a large dataset, it could not be generalized to patients in Asia. Further studies using large datasets of patients from different ethnicities should be performed to develop a nomogram applicable to patients worldwide.
