Interstitial Nephritis Caused by Anorexia Nervosa in Young Male; A Case Report and Literature Review.
- Author:
Ji Wook CHOI
1
;
Soon Kil KWON
;
Sun Moon KIM
;
Hyunjeong CHO
;
Ho chang LEE
;
Hye Young KIM
Author Information
- Publication Type:Case Report
- Keywords: Interstitial nephritis; anorexia; hypokalemia; tubular necrosis
- MeSH: Acute Kidney Injury; Adult; Anorexia Nervosa*; Anorexia*; Biopsy; Blood Gas Analysis; Carbon Dioxide; Eating; Humans; Hydrogen-Ion Concentration; Hypokalemia; Ischemia; Magnesium; Male*; Necrosis; Nephritis, Interstitial*; Partial Pressure; Potassium; Sodium; Urea; Vomiting
- From:Electrolytes & Blood Pressure 2018;16(1):15-17
- CountryRepublic of Korea
- Language:English
- Abstract: Severe eating disorders characterized by repetitive episodes of purging and vomiting can occasionally trigger acute kidney injury. However, interstitial nephritis induced by episodes of repeated vomiting has rarely been reported, and the pathophysiology of this entity remains unknown. A 26-year-old man was admitted to our hospital because of known hypokalemia. His serum electrolyte profile showed: sodium 133 mEq/L, potassium 2.6 mEq/L, chloride 72 mEq/L, total carbon dioxide 50 mEq/L, blood urea nitrogen/creatinine ratio (BUN/Cr) 21.9/1.98 mg/dL, and magnesium 2.0 mg/dL. Arterial blood gas analysis showed: pH 7.557, partial pressure of carbon dioxide 65.8 mmHg, and bicarbonate 58.5 mEq/L. His urinary potassium concentration was 73.2 mEq/L, and Cr was 111 mg/dL. Renal biopsy revealed acute tubular necrosis and tubulointerstitial nephritis with a few shrunken glomeruli. Repeated psychogenic vomiting may precipitate acute kidney injury and interstitial nephritis secondary to volume depletion and hypokalemia. Serum electrolyte levels and renal function should be carefully monitored in patients diagnosed with eating disorders to prevent tubular ischemia and interstitial nephritis.
