The Role of Advanced Glycation End Products in Diabetic Vascular Complications.
- Author:
Sang Youl RHEE
1
;
Young Seol KIM
Author Information
- Publication Type:Review
- Keywords: Diabetes complications; Glycation end products, advanced; Receptor for advanced glycation end products
- MeSH: Diabetes Complications; Diabetic Angiopathies*; Glucose; Glycosylation End Products, Advanced*; Humans; Hyperglycemia; Risk Factors
- From:Diabetes & Metabolism Journal 2018;42(3):188-195
- CountryRepublic of Korea
- Language:English
- Abstract: In cases of chronic hyperglycemia, advanced glycation end-products (AGEs) are actively produced and accumulated in the circulating blood and various tissues. AGEs also accelerate the expression of receptors for AGEs, and they play an important role in the development of diabetic vascular complications through various mechanisms. Active interventions for glucose and related risk factors may help improve the clinical course of patients by reducing AGEs. This review summarizes recent updates on AGEs that have a significant impact on diabetic vascular complications.
