Brain Perfusion Correlates of Apathy in Alzheimer's Disease.
10.12779/dnd.2018.17.2.50
- Author:
Hyeonseok JEONG
1
;
Ilhyang KANG
;
Jooyeon J IM
;
Jong Sik PARK
;
Seung Hee NA
;
Youngje HEO
;
YoungSoon YANG
;
Yong An CHUNG
;
In Uk SONG
Author Information
1. Department of Radiology, Incheon St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Alzheimer's Disease;
Apathy;
Tomography, Emission-Computed, Single-Photon;
Regional Blood Flow
- MeSH:
Alzheimer Disease*;
Apathy*;
Brain*;
Cerebrovascular Circulation;
Humans;
Nucleus Accumbens;
Perfusion*;
Prefrontal Cortex;
Putamen;
Regional Blood Flow;
Thalamus;
Tomography, Emission-Computed;
Tomography, Emission-Computed, Single-Photon
- From:Dementia and Neurocognitive Disorders
2018;17(2):50-56
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND PURPOSE: Apathy is one of the most common neuropsychiatric symptoms in patients with Alzheimer's disease (AD). It may have adverse impacts on the progression of AD. However, its neurobiological underpinnings remain unclear. The objective of this study was to investigate differences in regional cerebral blood flow (rCBF) between AD patients with apathy and those without apathy. METHODS: Sixty-six apathetic AD patients and 66 AD patients without apathy completed Neuropsychiatric Inventory (NPI) and underwent technetium-99m hexamethylpropylene amine oxime single-photon emission computed tomography (SPECT) scans. Voxel-wise differences in rCBF between the 2 groups were examined. Association between rCBF and levels of apathy in the apathetic group was also assessed. RESULTS: AD patients with apathy showed lower rCBF in the bilateral orbitofrontal cortex, left putamen, left nucleus accumbens, left thalamus, and bilateral insula than those without (all p < 0.005). Mean perfusion across all significant clusters showed a negative linear correlation with NPI apathy score in AD patients with apathy (β = −0.25; p = 0.04). CONCLUSIONS: Hypoperfusion in the prefrontal, striatal, and insular areas may be neural correlates of apathy in AD patients.
