Comparison of Sporadic Sclerotic Fibroma and Solitary Fibrous Tumor in the Oral Cavity.
10.3349/ymj.2007.48.3.535
- Author:
Ju Han LEE
1
;
Jung Suk AN
;
Eung Seok LEE
;
Soon Young KWON
;
Young Sik KIM
Author Information
1. Department of Pathology, Ansan Hospital, Medical College, Korea University, Ansan, Korea. apysk@korea.ac.kr
- Publication Type:Case Report ; Comparative Study
- Keywords:
Sclerotic fibroma;
solitary fibrous tumor;
oral cavity;
bcl-2
- MeSH:
Adult;
Antigens, CD/analysis;
Antigens, CD34/analysis;
Cell Adhesion Molecules/analysis;
Diagnosis, Differential;
Female;
Fibroma/*diagnosis/metabolism;
Humans;
Immunohistochemistry;
Mouth/chemistry/*pathology;
Mouth Neoplasms/*diagnosis/metabolism;
Neoplasms, Fibrous Tissue/*diagnosis/metabolism;
Proto-Oncogene Proteins c-bcl-2/analysis;
Vimentin/analysis
- From:Yonsei Medical Journal
2007;48(3):535-539
- CountryRepublic of Korea
- Language:English
-
Abstract:
Sporadic sclerotic fibroma (SF) and solitary fibrous tumor (SFT) arising in the oral cavity are very rare. In this report, we describe two cases of oral pathology, one involving SF and the other involving SFT. Both cases presented with well- circumscribed, firm nodules with similar gross findings. However, the histologic findings of the SF and SFT showed rather distinct features. The SF was composed of hyalinized sclerotic collagen bundles arranged in a whorled pattern, whereas the SFT was formed by spindles cells arranged in hypo- and hypercellular areas. The immunohistochemical findings were similar in both cases; there was positivity for vimentin, CD34, and CD99, but bcl-2 positivity was only seen in the SFT. Although their histopathologies are similar, SF and SFT should be considered in the differential diagnosis of soft tissue tumors in the oral cavity.
