Vocal Fold Regeneration: Current Review.
10.3342/kjorl-hns.2018.00346
- Author:
Choung Soo KIM
1
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Daejeon St. Mary's Hospital, Daejeon, Korea. drchoung@catholic.ac.kr
- Publication Type:Review
- Keywords:
Regenerative medicine;
Scaffold;
Stem cell;
Tissue engineering;
Vocal fold
- MeSH:
Cicatrix;
Extracellular Matrix;
Intercellular Signaling Peptides and Proteins;
Regeneration*;
Regenerative Medicine;
Stem Cell Transplantation;
Stem Cells;
Tissue Engineering;
Vocal Cords*;
Voice
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2018;61(6):275-280
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The extracellular matrix (ECM) of the vocal folds cannot be replaced after severe injury, but heal as scars. Scarred vocal folds cause voice problems. Many treatments have been attempted for vocal fold scarring, but their effectiveness is limited because the ECM composition does not normalize. Therefore, until now the prevention of scar formation has been important. In the field of regenerative medicine, cell therapies such as stem cell transplantation, and the implantation of several types of growth factors with or without scaffolds have been used. In this article, we reviewed the published research related to vocal fold regeneration and tried to think about the limitations of current studies and the future direction of treatment.
