Administration of Alpha(s1)-Casein Hydrolysate Increases Sleep and Modulates GABA(A) Receptor Subunit Expression.
10.4062/biomolther.2017.083
- Author:
Taddesse YAYEH
1
;
Yea Hyun LEEM
;
Kyung Mi KIM
;
Jae Chul JUNG
;
Jessica SCHWARZ
;
Ki Wan OH
;
Seikwan OH
Author Information
1. Department of Molecular Medicine and TIDRC, School of Medicine, Ewha Womans University, Seoul 07985, Republic of Korea. skoh@ewha.ac.kr
- Publication Type:Original Article
- Keywords:
Sleep;
α(S1)-CH;
Electroencephalogram;
GABA(A) receptor
- MeSH:
Animals;
Caseins*;
Electroencephalography;
Hypothalamus;
Mental Health;
Mice;
Neurodegenerative Diseases;
Neurons;
Rats;
Receptors, GABA-A*;
Sleep Wake Disorders;
Wakefulness
- From:Biomolecules & Therapeutics
2018;26(3):268-273
- CountryRepublic of Korea
- Language:English
-
Abstract:
Sleep is the most basic and essential physiological requirement for mental health, and sleep disorders pose potential risks of metabolic and neurodegenerative diseases. Tryptic hydrolysate of α(S1)-casein (α(S1)-CH) has been shown to possess stress relieving and sleep promoting effects. However, the differential effects of α(S1)-CH on electroencephalographic wave patterns and its effects on the protein levels of γ-aminobutyric acid A (GABA(A)) receptor subtypes in hypothalamic neurons are not well understood. We found α(S1)-CH (120, 240 mg/kg) increased sleep duration in mice and reduced sleep-wake cycle numbers in rats. While α(S1)-CH (300 mg/kg) increased total sleeping time in rats, it significantly decreased wakefulness. In addition, electroencephalographic theta (θ) power densities were increased whereas alpha (α) power densities were decreased by α(S1)-CH (300 mg/kg) during sleep-wake cycles. Furthermore, protein expressions of GABA(A) receptor β1 subtypes were elevated in rat hypothalamus by α(S1)-CH. These results suggest α(S1)-CH, through GABA(A) receptor modulation, might be useful for treating sleep disorders.
