Protective and therapeutic effects of an extract mixture of alder tree, labiate herb, milk thistle green bean-rice bran fermentation, and turnip against ethanol-induced toxicity in the rat.
- Author:
Min Won BAEK
1
;
Seung Hyeok SEOK
;
Hui Young LEE
;
Dong Jae KIM
;
Byoung Hee LEE
;
Young Tae AHN
;
Kwang Sei LIM
;
Chul Sung HUH
;
Jae Hak PARK
Author Information
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords: ethanol-induced toxicity; herbal extract mixture; protective effect; rat; yogurt
- MeSH: Alnus/*chemistry; Animals; Body Weight/drug effects; Brassica napus/*chemistry; Disease Models, Animal; Dose-Response Relationship, Drug; Eating; Ethanol/antagonists & inhibitors/*toxicity; Fabaceae/*chemistry; Fermentation; Liver/pathology; Male; Milk Thistle/*chemistry; Oryza sativa/*chemistry; Phytotherapy; Plant Extracts/*therapeutic use; Rats; Rats, Sprague-Dawley; Yogurt
- From:Journal of Veterinary Science 2008;9(1):31-37
- CountryRepublic of Korea
- Language:English
- Abstract: An herbal extract mixture and yogurt added to the herbal extract mixture were tested for their protective and therapeutic effects on ethanol-induced liver injury. The herbal extract mixture, yogurt and commercial drugs were used for treatment for two weeks prior to administering a single oral dose of ethanol (3 g/kg body weight). The herbal extract mixture and yogurt added to the herbal extract mixture were found to provide protection against ethanolinduced toxicity comparable to the commercial drug treatment, according to the serum and histopathological analysis. It was also shown that co-treatment with herbal extract mixture and yogurt against a triple oral dose of ethanol (2 g/kg body weight, over one week) provided protection against ethanol toxicity. After the initial set of experiments, the herbal extract mixture and yogurt treatments were extended for three more weeks. When compared to the positive control, further treatment with both the herbal extract and yogurt significantly reduced liver injury and resulted in a lower grade of lipid deposition.
