A score system for complete cytoreduction in selected recurrent ovarian cancer patients undergoing secondary cytoreductive surgery: predictors- and nomogram-based analyses.
- Author:
Giorgio BOGANI
1
;
Elena TAGLIABUE
;
Mauro SIGNORELLI
;
Antonino DITTO
;
Fabio MARTINELLI
;
Valentina CHIAPPA
;
Lavinia MOSCA
;
Ilaria SABATUCCI
;
Umberto LEONE ROBERTI MAGGIORE
;
Domenica LORUSSO
;
Francesco RASPAGLIESI
Author Information
- Publication Type:Original Article
- Keywords: Ovarian Neoplasms; Recurrence; Cytoreduction Surgical Procedures
- MeSH: Cytoreduction Surgical Procedures; Humans; Nomograms; Ovarian Neoplasms*; Recurrence; Retrospective Studies
- From:Journal of Gynecologic Oncology 2018;29(3):e40-
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: To test the applicability of the Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) and Memorial Sloan Kettering (MSK) criteria in predicting complete cytoreduction (CC) in patients undergoing secondary cytoreductive surgery (SCS) for recurrent ovarian cancer (ROC). METHODS: Data of consecutive patients undergoing SCS were reviewed. The Arbeitsgemeinschaft Gynäkologische Onkologie OVARian cancer study group (AGO-OVAR) and MSK criteria were retrospectively applied. Nomograms, based on AGO criteria, MSK criteria and both AGO and MSK criteria were built in order to assess the probability to achieve CC at SCS. RESULTS: Overall, 194 patients met the inclusion criteria. CC was achieved in 161 (82.9%) patients. According to the AGO-OVAR criteria, we observed that CC was achieved in 87.0% of patients with positive AGO score. However, 45 out of 71 (63.4%) patients who did not fulfilled the AGO score had CC. Similarly, CC was achieved in 87.1%, 61.9% and 66.7% of patients for whom SCS was recommended, had to be considered and was not recommended, respectively. In order to evaluate the predictive value of the AGO-OVAR and MSK criteria we built 2 separate nomograms (c-index: 0.5900 and 0.5989, respectively) to test the probability to achieve CC at SCS. Additionally, we built a nomogram using both the aforementioned criteria (c-index: 0.5857). CONCLUSION: The AGO and MSK criteria help identifying patients deserving SCS. However, these criteria might be strict, thus prohibiting a beneficial treatment in patients who do not met these criteria. Further studies are needed to clarify factors predicting CC at SCS.
