Quetiapine Related Acute Paralytic Ileus in a Bipolar I Disorder Patient with Successful Low Dose Amisulpride Substitution: A Case Report.
10.9758/cpn.2018.16.2.228
- Author:
Shun Ting CHIANG
1
;
Chen Chia LAN
Author Information
1. Department of Psychiatry, Taichung Veterans General Hospital, Taichung, Taiwan. drblue3305@gmail.com
- Publication Type:Case Report
- Keywords:
Bipolar disorder;
Paralytic ileus;
Constipation;
Quetiapine;
Amisulpride;
Anticholinergics
- MeSH:
Bipolar Disorder;
Cholinergic Antagonists;
Constipation;
Female;
Humans;
Intestinal Pseudo-Obstruction*;
Middle Aged;
Quetiapine Fumarate*;
Recurrence;
Risk Factors
- From:Clinical Psychopharmacology and Neuroscience
2018;16(2):228-231
- CountryRepublic of Korea
- Language:English
-
Abstract:
The mechanism of medication-induced gastrointestinal hypomotility is primarily caused by muscarinic cholinergic antagonism. This effect may cause constipation and paralytic ileus, which may lead to fatal complications. A 51-year-old woman was admitted due to manic episode recurrence. She developed paralytic ileus under quetiapine use and treated successfully under low dose amisulpride use. The related mechanism, associated risk factors, and the rationale for medication switch are discussed.
