Prevalence of and factors associated with anxiety and depression in Korean patients with newly diagnosed advanced gastrointestinal cancer.
- Author:
Junghwa CHUNG
1
;
Gawon JU
;
Jiyoul YANG
;
Jiwon JEONG
;
Yusook JEONG
;
Moon Ki CHOI
;
Jihyun KWON
;
Ki Hyeong LEE
;
Seung Taik KIM
;
Hye Sook HAN
Author Information
- Publication Type:Original Article
- Keywords: Anxiety; Neoplasms; Depression; Gastrointestinal
- MeSH: Anxiety*; Appetite; Depression*; Drug Therapy; Fatigue; Gastrointestinal Neoplasms*; Global Health; Humans; Multivariate Analysis; Prevalence*; Prospective Studies; Quality of Life; Stomach Neoplasms
- From:The Korean Journal of Internal Medicine 2018;33(3):585-594
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: The purpose of the present study was to assess the prevalence of and factors associated with anxiety and depression in Korean patients with advanced gastrointestinal cancer. METHODS: One hundred and twenty consecutive patients with newly diagnosed, advanced gastrointestinal cancer who were scheduled to receive palliative chemotherapy between July 2012 and June 2014 were enrolled in this observational prospective study. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS) and Patient Health Questionnaire-9 (PHQ-9). RESULTS: Thirty-seven patients (30.8%) had anxiety or depression with clinical significance according to HADS or PHQ-9. Multivariate analysis identified lower performance status (odds ratio [OR], 4.19; 95% confidence interval [CI], 1.22 to 14.35; p = 0.023), gastric cancer (OR, 5.39; 95% CI, 0.37 to 78.23; p = 0.018), and knowledge of advanced cancer (OR, 15.07; 95% CI, 1.80 to 125.90; p = 0.012) as significantly associated with anxiety or depression. Twenty-one patients with anxiety or depression visited the psycho-oncologic clinic. In these patients, PHQ-9 score (p = 0.008), global health status (p = 0.023), fatigue (p = 0.047), and appetite loss (p = 0.006) improved from baseline to 3 months after study enrollment. CONCLUSIONS: Approximately 30% of Korean patients with advanced gastrointestinal cancer had anxiety or depression. The prevalence of anxiety or depression was higher in patients with poor performance status, gastric cancer, or knowledge of advanced cancer. Psychiatric interventions may be effective in reducing depression and improving quality of life in cancer patients with anxiety or depression.
