Daclatasvir Plus Asunaprevir for the Treatment of Patients with Hepatitis C Virus Genotype 1b Infection: Real-World Efficacy, Changes in Liver Stiffness and Fibrosis Markers, and Safety.
- Author:
Hye Won LEE
1
;
Se Rim OH
;
Dong Yun KIM
;
Yechan JEONG
;
Seungtaek KIM
;
Beom Kyung KIM
;
Seung Up KIM
;
Do Young KIM
;
Sang Hoon AHN
;
Kwang Hyub HAN
;
Jun Yong PARK
Author Information
- Publication Type:Original Article
- Keywords: Daclatasvir; Asunaprevir; Hepatitis C; Genotype 1b; Fibrosis
- MeSH: Aspartic Acid; Female; Fibrosis*; Genotype; Hepacivirus*; Hepatitis C*; Hepatitis C, Chronic; Hepatitis*; Humans; Liver Cirrhosis; Liver*; Male; RNA
- From:Gut and Liver 2018;12(3):324-330
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: The treatment with daclatasvir plus asunaprevir (DCV+ASV) is associated with potent antiviral effects in patients with genotype 1b hepatitis C virus (HCV) infection. We investigated the real-world efficacy, changes in liver stiffness and noninvasive fibrosis markers, and the safety of DCV+ASV treatment in Korean patients. METHODS: In total, 363 patients with chronic hepatitis C were treated with DCV+ASV between August 2015 and January 2017. Finally, we analyzed the data of 270 patients who were monitored for at least 12 weeks after the end of treatment. RESULTS: The mean age was 60.7 years, and females predominated (60.4%). Most patients (64.8%) were treatment-naïve, and 56 patients (20.7%) had cirrhosis. Two hundred fifty-seven (95.2%) and 251 (93.0%) patients achieved end-of-treatment responses and sustained virological responses at 12 weeks posttreatment (SVR12), respectively. The SVR12 rates were higher in patients who were < 65 years of age, males, without cirrhosis and had lower HCV RNA levels. All LS values and fibrosis-4 and aspartate aminotransferase-to-platelet ratio index values declined from baseline to the time of assessment of SVR12. CONCLUSIONS: The DCV+ASV therapy resulted in a high SVR12 and improved liver fibrosis; the treatment was well tolerated in patients with genotype 1b HCV infections.
