Analysis of Adverse Cutaneous Drug Reactions using an Electronic Drug Adverse Reaction Reporting System at a Single Secondary Referral Center: A Retrospective Study.
- Author:
Cheong Ha WOO
1
;
Mira CHOI
;
Han Jeong YUN
;
Hai Jin PARK
Author Information
1. Department of Dermatology, Ilsan Paik Hospital, College of Medicine, Inje University, Goyang, Korea. stratum@paik.ac.kr
- Publication Type:Original Article
- Keywords:
Adverse drug reaction;
Adverse drug reaction reporting systems;
Drug-related side effects and adverse reactions
- MeSH:
Acetic Acid;
Adverse Drug Reaction Reporting Systems;
Anti-Bacterial Agents;
Anti-Inflammatory Agents, Non-Steroidal;
Cephalosporins;
Contrast Media;
Diethylpropion;
Drug-Related Side Effects and Adverse Reactions;
Eosinophilia;
Exanthema;
Heart;
Heart Diseases;
Humans;
Mortality;
Pruritus;
Quinolones;
Retrospective Studies*;
Secondary Care Centers*;
Urticaria
- From:Korean Journal of Dermatology
2018;56(4):251-258
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Adverse cutaneous drug reactions (ACDRs) are common and are responsible for increased morbidity, mortality, and socioeconomic costs. OBJECTIVE: The purpose of our study was to investigate the common drugs and clinical patterns related to ACDRs using an electronic drug adverse reaction reporting system at a single secondary referral center. METHODS: We conducted a retrospective analysis of the ACDR database between January 2014 and April 2016 at the Ilsan Paik Hospital. RESULTS: The study analyzed 320 patients with ACDRs (male:female ratio=93:227; mean age 50.8±17.8 years). Using a Korean causality evaluation algorithm, the percentage of drugs with a possible relationship with ACDRs was calculated to be 50.6%, while the percentage with a probable relationship was 44.7%. Antibiotics (44.0%), radiocontrast media (15.1%), and non-steroidal anti-inflammatory drugs (NSAIDs) (14.3%) were the most commonly implicated drugs. Antibiotics, including cephalosporins (30.6%) and quinolones (10.2%), were responsible for the majority of the ACDRs. Acetic acid (5.9%) and propionic acid (5.9%) derivatives of NSAIDs were also common causative agents. The most common clinical presentations were maculopapular exanthema (33.4%), pruritus (30.9%), and urticaria (25.7%). Severe ACDRs were significantly associated with older age, eosinophilia, and underlying heart and renal diseases (p<0.05). CONCLUSION: Antibiotics, radiocontrast media, and NSAIDs were identified as common causes of ACDRs. Older age, eosinophilia, heart disease, and renal disease were associated with severe ACDRs.
