Correlations of Four Genetic Single Nucleotide Polymorphisms in Brain-Derived Neurotrophic Factor with Posttraumatic Stress Disorder.
- Author:
Jun Cheng GUO
1
;
Yi Jun YANG
;
Min GUO
;
Xiao Dan WANG
;
Yang JUAN
;
Yun Suo GAO
;
Lin Qiu FU
;
Xiang Ling JIANG
;
Lin Mei FU
;
Tao HUANG
Author Information
- Publication Type:Original Article
- Keywords: Brain-derived neurotrophic factor; Posttraumatic stress disorder; Gene polymorphism
- MeSH: Alleles; Brain-Derived Neurotrophic Factor*; Gene Frequency; Genotype; Healthy Volunteers; Humans; Polymerase Chain Reaction; Polymorphism, Single Nucleotide*; Sequence Analysis, DNA; Stress Disorders, Post-Traumatic*
- From:Psychiatry Investigation 2018;15(4):407-412
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: To investigate the correlations of four genetic single nucleotide polymorphisms (SNPs) of brain-derived neurotrophic factor (BDNF) with posttraumatic stress disorder (PTSD). METHODS: A total of 300 patients with sporadic PTSD and 150 healthy subjects (the control group) were selected according to the diagnostic criteria of PTSD (DSM-IV), and the genotypes of the BDNF SNPs G-712A, C270T, rs6265, and rs7103411 were detected by polymerase chain reaction and direct DNA sequencing to determine intergroup differences in the genotypes and allele frequencies; the p values were corrected with the permutation test. RESULTS: The genotypes and allele frequencies of the SNPs G-712A, rs6265, and rs7103411 of BDNF showed no significant intergroup differences (p>0.05). However, the genotype and allele frequencies of C270T showed significant differences between the PTSD group and the control group (p<0.05). CONCLUSION: The SNP C270T of BDNF may be associated with PTSD. Individuals carrying the polymorphic T allele of C270T may be more likely to suffer from PTSD.
