Childhood Venous Thromboembolism in Yeungnam Region in Korea: Multicenter Study.
10.15264/cpho.2018.25.1.43
- Author:
Soram LEE
1
;
Jong Hyuk YOUN
;
Jae Young LIM
;
Hee Won CHUEH
;
Jae Min LEE
;
Jin Kyung SUH
;
Ji Yoon KIM
;
Eu Jeen YANG
;
Kyung Mi PARK
;
Young Tak LIM
;
Jikyoung PARK
;
Eun Mi CHOI
;
Ye Jee SHIM
;
Heung Sik KIM
;
Sang Kyu PARK
;
Seom Gim KONG
;
Eun Jin CHOI
;
Eun Sil PARK
Author Information
1. Department of Pediatrics, Gyeongsang National University College of Medicine, Jinju, Korea. espark@gnu.ac.kr
- Publication Type:Multicenter Study ; Original Article
- Keywords:
Venous thromboembolism;
Pediatric patients;
Epidemiology
- MeSH:
Abdomen;
Adult;
Catheters;
Child;
Diagnosis;
Epidemiology;
Health Personnel;
Homocysteine;
Hospitals, University;
Humans;
Incidence;
Korea*;
Lower Extremity;
Magnetic Resonance Imaging;
Male;
Medical Records;
Pediatrics;
Prognosis;
Protein C;
Protein S;
Retrospective Studies;
Risk Factors;
Thrombosis;
Upper Extremity;
Venous Thromboembolism*
- From:Clinical Pediatric Hematology-Oncology
2018;25(1):43-49
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Venous thromboembolism (VTE) is rare in pediatric patients compared to adults, but it's incidence is gradually increasing. The purpose of this study was to analyze the incidence, risk factors, and prognosis of pediatric patients with VTE in Korea. METHODS: Between January 2000 and July 2017, 249,312 medical records of the patients older than 1 year who were hospitalized in the department of pediatrics of 10 university hospitals in Yeungnam region were retrospectively reviewed. RESULTS: The overall incidence of VTE was 4.9 per 10,000 admissions. Of the total 123 patients, 80 (65.0%) were male and the median age was 10.8 years (range, 1.0–23.5 years). Magnetic resonance imaging was performed most frequently to confirm the diagnosis of VTE (43.1%). Thrombosis occurred in the cerebral vessels (46.3%), lower extremities (23.8%), pulmonary (19.5%), abdomen (9.8%), and upper extremities (4.1%). One hundred and six patients had underlying causes such as cancer (27.6%), infection (26.8%), intravenous catheter insertion (17.9%), and surgery (14.6%). Protein C was evaluated in 39 patients (31.7%), protein S in 40 (32.5%), antithrombin (AT) III in 52 (42.3%), and homocysteine in 21 (17.1%). Among them, one patient with a family history of AT III deficiency had SERPINC gene mutation. Seventy-seven patients (62.6%) started anticoagulation treatment. Most (52.0%) were treated for more than 90 days. CONCLUSION: Healthcare providers must be aware of the potential for VTE development in childhood. In the near future, a nationwide survey should be investigated to determine the incidence rate and the trends in VTE among Korean children.
