Effects of Low- or Moderate-dose Whole Body-X-ray Radiation on the Immune System of C57BL/6 Mice.
10.15264/cpho.2018.25.1.50
- Author:
Yunmi KO
1
;
Yeon Ho JEONG
;
Jun Ah LEE
Author Information
1. Division of Radiological Science and Clinical Research, Korea Cancer Center Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Low-dose;
X-ray;
Radiation;
Immune system;
Mice
- MeSH:
Animals;
Blood Cell Count;
Diagnostic Imaging;
Humans;
Immune System*;
Lymphocyte Subsets;
Mice*;
Occupational Exposure;
Radiation Dosage
- From:Clinical Pediatric Hematology-Oncology
2018;25(1):50-55
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Increase in the use of diagnostic imaging or occupational exposure to radiation have brought upon concerns on the safety and biological effects of low- or moderate-dose radiation. However, limited information is available on the effects of low or moderate dose radiation on human health. METHODS: Using C57BL/6 mice, we aimed to evaluate the biological effects of low- and moderate-dose radiation on the immune system. X-rays was chosen as a radiation source and we analyzed complete blood counts, various lymphocyte subsets and various cytokine levels after single fraction x-ray exposure (0.1 Gy, 1 Gy). RESULTS: No significant changes in the immunologic parameter of C57BL/6 mice were observed after radiation, except LIX (a cytokine equivalent to human CXCL5), that showed higher level after 0.1 Gy radiation compared to the control. CONCLUSION: We observed that a single fraction of low or moderate dose of X-ray radiation does not cause significant changes in the immune system of C57BL/6 mice. Further studies are necessary to elucidate the mechanism underlying our results.
