Septic Arthritis and Infective Endocarditis in an Adolescent Hemophilia B Patient with an Inhibitor and a Central Venous Access Device.
10.15264/cpho.2018.25.1.61
- Author:
Jisu KIM
1
;
Young Shil PARK
Author Information
1. Department of Pediatrics, Kyung Hee University Hospital at Gangdong, Seoul, Korea. pysmd@khnmc.or.kr
- Publication Type:Case Report
- Keywords:
Central venous access devices;
Hemophilia B;
Ventricular septal defect;
Infective endocarditis;
Septic arthritis
- MeSH:
Adolescent*;
Arthritis, Infectious*;
Bacteremia;
Child;
Endocarditis*;
Heart Defects, Congenital;
Heart Septal Defects, Ventricular;
Hemophilia A*;
Hemophilia B*;
Humans;
Methicillin-Resistant Staphylococcus aureus;
Risk Factors
- From:Clinical Pediatric Hematology-Oncology
2018;25(1):61-65
- CountryRepublic of Korea
- Language:English
-
Abstract:
Central venous access devices (CVAD) provide hemophilic patients, particularly children, with prolonged reliable venous access to promote routine factor replacement therapy. However, one of the significant complications of CVAD use is infection. We report the case of a severe hemophilia B patient with an inhibitor who developed septic arthritis and infective endocarditis associated with methicillin-resistant Staphylococcus aureus infection originating from a CVAD. Our patient had an underlying condition of congenital heart disease, one of the risk factors for infective endocarditis. Unfortunately, the antibiotic therapy did not have a significant effect. An echocardiogram revealed vegetation on the right ventricular moderate band and surgery was determined to be the best course of action. Septic arthritis and endocarditis rarely occur in hemophilia patients, however, they must be taken into account in hemophiliacs with continuing bacteremia.
