A Case of Erdheim-Chester Disease Developed during Treatment of Leukemia in a Child.
10.15264/cpho.2018.25.1.66
- Author:
Joon Pyo HONG
1
;
Won Ki AHN
;
Joo Yeon LIM
;
Jo Eun JUNG
;
Seung Min HAHN
;
Jung Woo HAN
;
Chuhl Joo LYU
Author Information
1. Division of Pediatric Hematology and Oncology, Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea. CJ@yuhs.ac
- Publication Type:Case Report
- Keywords:
Erdheim-Chester disease;
Acute lymphoblastic leukemia;
Child
- MeSH:
Biopsy;
Bone Marrow;
Child*;
Chimerism;
Erdheim-Chester Disease*;
Hematopoietic Stem Cell Transplantation;
Histiocytes;
Histiocytosis;
Humans;
Leukemia*;
Male;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
Vinblastine
- From:Clinical Pediatric Hematology-Oncology
2018;25(1):66-70
- CountryRepublic of Korea
- Language:English
-
Abstract:
Erdheim-Chester disease (ECD) is a rare non-Langerhan's cell histiocytosis disorder characterized by replacement of normal tissue by lipid-laden histiocytes affecting various organs. A few pediatric cases have been reported worldwide. Here we present a child with leukemia who was diagnosed as ECD. A 2-year and 11-month old boy diagnosed with high risk acute lymphoblastic leukemia (ALL) at the age of 17 months, received allogeneic hematopoietic stem cell transplantation (HSCT) at the age of 2 years old. Six months after the transplantation, the patient was admitted to the hospital with palpable left calf nodules. Bone marrow study suggested ECD without leukemia with complete chimerism status. Excisional biopsy of the left calf nodule showed ‘aggregation of non-Langerhan's cell type epitheloid histiocytes’; clinically suggestive of ECD. The patient was started on vinblastine and corticosteroid treatment.
