Evaluation of the drug-induced lymphocyte stimulation test for diagnosing mesalazine allergy.
- Author:
Daisuke SAITO
1
;
Mari HAYASHIDA
;
Taro SATO
;
Shintaro MINOWA
;
Osamu IKEZAKI
;
Tatsuya MITSUI
;
Miki MIURA
;
Akihito SAKURABA
;
Tadakazu HISAMATSU
Author Information
- Publication Type:Original Article
- Keywords: Mesalamine; Drug-induced lymphocyte stimulation test; Colitis, ulcerative
- MeSH: Colitis, Ulcerative; Diagnosis; Humans; Hypersensitivity*; Lymphocyte Activation*; Lymphocytes*; Mesalamine*; Sensitivity and Specificity
- From:Intestinal Research 2018;16(2):273-281
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Mesalazine is an effective drug for treating ulcerative colitis (UC), but causes allergic symptoms in a few cases. Therefore, the objective of this study was to evaluate the usefulness of the drug-induced lymphocyte stimulation test (DLST) for the diagnosis of mesalazine allergy. METHODS: Patients with UC treated with mesalazine with or without a history of associated adverse events (AEs) were enrolled at Kyorin University Hospital from July 2016 to April 2017. RESULTS: The DLST was performed in 104 patients with UC, of which 24 had a history of AEs due to mesalazine treatment. The control value of DLST was 337.4±296.3 counts per minute (cpm) in the AE+ group and 408.0±371.9 cpm in the AE− group. The measured value of DLST was 578.8±424.7 cpm in the AE+ group and 476.5±471.8 cpm in the AE− group. The stimulation index (SI) was 243.9%±291.1% in the AE+ group and 119.8%±53.0% in the AE− group. The SI value and DLST positivity were significantly higher in the AE+ group than in the AE− group (P=0.030 and P=0.029, respectively). The test sensitivity and specificity were 0.240 and 0.805, respectively, and the false-positive and false-negative rate was 0.195 and 0.760, respectively. CONCLUSIONS: The DLST for mesalazine showed low sensitivity and high specificity, suggesting that it may be useful for the definitive diagnosis of allergy to mesalazine.
