Pathogenesis of Recalcitrant Chronic Rhinosinusitis: The Emerging Role of Innate Immune Cells.
- Author:
Il Gyu KONG
1
;
Dae Woo KIM
Author Information
- Publication Type:Review
- Keywords: Chronic rhinosinusitis; Nasal polyps; Recalcitrant chronic rhinosinusitis; Pathogenesis; Innate immune cell
- MeSH: Eosinophils; Epithelial Cells; Lymphocytes; Macrophages; Nasal Polyps; Neutrophils; Phenotype; T-Lymphocytes
- From:Immune Network 2018;18(2):e6-
- CountryRepublic of Korea
- Language:English
- Abstract: Chronic rhinosinusitis (CRS) is a major part of the recalcitrant inflammatory diseases of the upper airway that needs enormous socioeconomic burden. T helper (Th) 2 type immune responses recruiting eosinophils were the most well-known immune players in CRS pathogenesis especially in western countries. By the piling up of a vast amount of researches to elucidate the pathogenic mechanism of CRS recently, heterogeneous inflammatory processes were found to be related to the phenotypes of CRS. Recently more cells other than T cells were in the focus of CRS pathogenesis, such as the epithelial cell, macrophage, innate lymphoid cells, and neutrophils. Here, we reviewed the recent research focusing on the innate immune cells related to CRS pathogenesis.
